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公开(公告)号：EP1204665B1
公开(公告)日：2009-01-07
申请号：EP00950880.5
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D491/044 , A61K31/4353 , A61K31/4365 , A61K31/55 , A61K31/451 , A61P29/00 , C07D409/06 , C07D401/06 , C07D211/52 , C07D405/06 , C07D471/04 , C07D519/00 , C07D495/04
CPC分类号： C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (I) or (II) and physiologically acceptable salts thereof.
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2.发明授权CCR1 ANTAGONISTS FOR THE TREATMENT OF I.A. DEMYELINATING INFLAMMATORY DISEASE 有权CCR1受体拮抗剂于治疗U.A. 脱髓鞘炎性疾病
公开(公告)号：EP1562954B1
公开(公告)日：2006-05-03
申请号：EP03768852.0
申请日：2003-11-12
IPC分类号： C07D491/04 , C07D313/00 , C07D221/00
CPC分类号： C07D491/044 , C07D491/04
摘要： The invention provides compounds having the formula (I): wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
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公开(公告)号：EP1507756B1
公开(公告)日：2015-07-22
申请号：EP03755422.7
申请日：2003-05-21
IPC分类号： C07C311/14 , C07C311/15 , C07D213/02 , C07D237/06 , C07D239/69 , A61K31/18 , A61K31/44 , A61K31/4965 , A61K31/505 , A61P29/00
CPC分类号： C07C311/29 , C07C311/21 , C07C311/44 , C07C311/46 , C07C317/34 , C07C323/49 , C07D213/46 , C07D213/50 , C07D213/65 , C07D213/70 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/89 , C07D237/08 , C07D239/26 , C07D239/42 , C07D333/34 , C07D333/62 , C07D401/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/14 , C07D513/04
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公开(公告)号：EP1202985A2
公开(公告)日：2002-05-08
申请号：EP00950864.9
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G. , BROWN, James, A.
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D213/36 , C07D491/10 , C07D471/10 , C07D498/10 , C07D495/10 , C07D413/14 , C07D417/14 , C07D451/06 , A61K31/4545 , A61K31/44 , A61P19/02
CPC分类号： C07D451/06 , C07D213/36 , C07D213/38 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/10 , C07D495/10
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (I) or (II) and physiologically acceptable salts thereof.
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5.发明公开CCR1 ANTAGONISTS FOR THE TREATMENT OF I.A. DEMYELINATING INFLAMMATORY DISEASE 有权CCR1受体拮抗剂于治疗U.A. 脱髓鞘炎性疾病
公开(公告)号：EP1562954A1
公开(公告)日：2005-08-17
申请号：EP03768852.0
申请日：2003-11-12
IPC分类号： C07D491/04
CPC分类号： C07D491/044 , C07D491/04
摘要： The invention provides compounds having the formula (I): wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
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公开(公告)号：EP1448566A2
公开(公告)日：2004-08-25
申请号：EP02789725.5
申请日：2002-11-13
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G. , GHOSH, Shomir , ELDER, Amy, M. , MATTIA, Karen, M.
IPC分类号： C07D491/04 , C07D471/04 , C07D519/00 , C07D513/04 , A61K31/4353 , A61K31/55 , A61P29/00 , A61P1/00 , A61P3/10
CPC分类号： C07D491/04 , C07D211/46
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
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公开(公告)号：EP1204640A2
公开(公告)日：2002-05-15
申请号：EP00952261.6
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D211/52 , A61K31/497 , A61K31/4523 , A61P29/00 , C07D405/06 , C07D493/04 , C07D409/06 , C07D495/04 , C07D491/04 , C07D401/06 , C07D401/14 , C07D471/04 , C07D519/00 , C07D313/12
CPC分类号： C07D401/06 , C07D211/52 , C07D313/12 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by structural formula (XXIV) or Z-Y-(CH2)n-X-NR50R5 and physiologically acceptable salts thereof.
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公开(公告)号：EP1448566B3
公开(公告)日：2009-04-08
申请号：EP02789725.5
申请日：2002-11-13
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G. , GHOSH, Shomir , ELDER, Amy, M. , MATTIA, Karen, M.
IPC分类号： C07D491/04 , C07D471/04 , C07D519/00 , C07D513/04 , A61K31/4353 , A61K31/55 , A61P29/00 , A61P1/00 , A61P3/10 , C07D313/00 , C07D221/00 , C07D223/00
CPC分类号： C07D491/04 , C07D211/46
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
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公开(公告)号：EP1735311A1
公开(公告)日：2006-12-27
申请号：EP05779267.3
申请日：2005-04-08
发明人： HEPPERLE, Michael, E. , LIU, Julie, Fields , SOUCY, Francois , PRAKASH, Raman , LITTLE, Jeremy, D. , FLEMING, Paul, E. , REYNOLDS, Dominic , HARRIMAN, Geraldine, C., B.
IPC分类号： C07D471/04 , A61K31/5377 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04
摘要： This invention provides beta-carboline compounds of formula III-A-aa, wherein Q, G, R1, R2, R3, and R6b are as described in the specification. The compounds are useful for treating diseases such as inflammatory diseases and cancer.
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公开(公告)号：EP1204664A1
公开(公告)日：2002-05-15
申请号：EP00952317.6
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D491/04 , C07D495/04 , C07D401/06 , C07D451/06 , C07D519/00 , C07D471/04 , A61K31/4353 , A61K31/436 , A61K31/4365 , A61K31/55 , A61P37/00
CPC分类号： C07D401/06 , C07D471/04 , C07D491/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (1) or Z-Y-(CH2)n -X-NR50R5 and physiologically acceptable salts thereof.
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