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公开(公告)号：EP2733147A1
公开(公告)日：2014-05-21
申请号：EP13191413.7
申请日：2009-06-16
发明人： Elliott, Eric L. , Ferdous, Abu J. , Kaufman, Michael J. , Komar, Sonja A. , Mazaik, Debra L. , McCubbin, Quentin J. , Nguyen, Phoung M. , Palaniappan, Vaithianathan , Skwierczynski, Raymond D. , Truong, Nobel T. , Varga, Csanad M. , Zawaneh, Peter N.
CPC分类号： C07F5/04 , A61K31/198 , A61K31/454 , A61K31/69 , C07C233/83 , C07F5/025 , C07K5/06139 , C07K5/06191
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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2.发明公开Process for the synthesis of intermediates compounds useful for the preparation of E1 activity activating enzyme inhibitors 审中-公开一种用于中间体的合成生产的E1活化酶活性的抑制剂处理
公开(公告)号：EP2546256A2
公开(公告)日：2013-01-16
申请号：EP12172363.9
申请日：2008-08-01
发明人： Armitage, Ian , Elliot, Eric L. , Langston, Marianne , Langston, Steven , McCubbin, Quentin J. , Mizutani, Hirotake , Stirling, Matthew , Zhu, Lei
IPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24
摘要： The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1 S , 2 S , 4 R )-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
摘要翻译： 本发明提供了方法和合成中间体4-取代的（（1S，2S，4R）-2-羟基-4- {7H-吡咯并[2,3-d]嘧啶-7-基}的合成 环戊基）氨基磺酸甲酯，哪些是E1活化酶抑制剂，并且可用于细胞增殖，特别是癌症，并且与E1活性相关的其它病症的病症的治疗是有用的。
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公开(公告)号：EP2546256B1
公开(公告)日：2019-10-09
申请号：EP12172363.9
申请日：2008-08-01
发明人： Armitage, Ian , Elliot, Eric L. , Langston, Marianne , Langston, Steven , McCubbin, Quentin J. , Mizutani, Hirotake , Stirling, Matthew , Zhu, Lei
IPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C307/04
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4.发明公开Process for the synthesis of intermediates compounds useful for the preparation of E1 activity activating enzyme inhibitors 审中-公开合成中间体化合物的方法，用于制备E1活性激活酶抑制剂
公开(公告)号：EP2546256A3
公开(公告)日：2013-04-17
申请号：EP12172363.9
申请日：2008-08-01
发明人： Armitage, Ian , Elliot, Eric L. , Langston, Marianne , Langston, Steven , McCubbin, Quentin J. , Mizutani, Hirotake , Stirling, Matthew , Zhu, Lei
IPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C307/04
摘要： The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1 S , 2 S , 4 R )-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
摘要翻译： 本发明提供了合成4-取代的（（1S，2S，4R）-2-羟基-4- {7H-吡咯并[2,3-d]嘧啶-7-基}环戊基）甲基的方法和合成中间体 氨基磺酸盐，其为E1激活酶抑制剂，并且可用于治疗细胞增殖病症，特别是癌症以及与E1活性相关的其他病症。
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公开(公告)号：EP2540727B1
公开(公告)日：2018-07-25
申请号：EP12172365.4
申请日：2008-08-01
IPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07D211/96 , C07D213/89 , C07D241/50 , C07D295/22 , C07D471/08 , C07B45/04 , C07C311/45 , C07C317/38
CPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C315/04 , C07C317/50 , C07C2601/08 , C07D211/96 , C07D213/89 , C07D241/50 , C07D295/22 , C07D305/08 , C07D471/08 , Y02P20/55
摘要： The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1 S , 2 S , 4 R )-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
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6.发明授权
公开(公告)号：EP2730581B1
公开(公告)日：2016-04-27
申请号：EP13191414.5
申请日：2009-06-16
发明人： Elliott, Eric L. , Ferdous, Abu J. , Kaufman, Michael J. , Komar, Sonja A. , Mazaik, Debra L. , McCubbin, Quentin J. , Nguyen, Phoung M. , Palaniappan, Vaithianathan , Skwierczynski, Raymond D. , Truong, Nobel T. , Varga, Csanad M. , Zawaneh, Peter N.
IPC分类号： C07F5/02 , C07K5/06 , C07F5/04 , C07K5/078 , A61K38/05 , A61K31/198 , A61K31/454 , A61K31/69 , C07C233/83 , A61P29/00 , A61P35/00
CPC分类号： C07F5/04 , A61K31/198 , A61K31/454 , A61K31/69 , C07C233/83 , C07F5/025 , C07K5/06139 , C07K5/06191
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公开(公告)号：EP2730581A1
公开(公告)日：2014-05-14
申请号：EP13191414.5
申请日：2009-06-16
发明人： Elliott, Eric L. , Ferdous, Abu J. , Kaufman, Michael J. , Komar, Sonja A. , Mazaik, Debra L. , McCubbin, Quentin J. , Nguyen, Phoung M. , Palaniappan, Vaithianathan , Skwierczynski, Raymond D. , Truong, Nobel T. , Varga, Csanad M. , Zawaneh, Peter N.
CPC分类号： C07F5/04 , A61K31/198 , A61K31/454 , A61K31/69 , C07C233/83 , C07F5/025 , C07K5/06139 , C07K5/06191
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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公开(公告)号：EP2730580A1
公开(公告)日：2014-05-14
申请号：EP13191412.9
申请日：2009-06-16
发明人： Elliott, Eric L. , FERDOUS, Abu J. , Kaufman, Michael J. , Komar, Sonja A. , Mazaik, Debra L. , McCubbin, Quentin J. , Nguyen, Phoung M. , Palaniappan, Vaithianathan , Skwierczynski, Raymond D. , Truong, Nobel T. , Varga, Csanad M. , Zawaneh, Peter N.
CPC分类号： C07F5/04 , A61K31/198 , A61K31/454 , A61K31/69 , C07C233/83 , C07F5/025 , C07K5/06139 , C07K5/06191
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供用作蛋白酶体抑制剂的新化合物。 本发明还提供了包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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9.发明公开Boronate ester compounds and pharmaceutical compositions thereof 审中-公开其Boronatesterverbindungen和药物组合物
公开(公告)号：EP2730579A1
公开(公告)日：2014-05-14
申请号：EP13191409.5
申请日：2009-06-16
发明人： Elliott, Eric L. , Ferdous, Abu J. , Kaufman, Michael J. , Komar, Sonja A. , Mazaik, Debra L. , McCubbin, Quentin J. , Nguyen, Phoung M. , Palaniappan, Vaithianathan , Skwierczynski, Raymond D. , Truong, Nobel T. , Varga, Csanad M. , Zawaneh, Peter N.
CPC分类号： C07F5/04 , A61K31/198 , A61K31/454 , A61K31/69 , C07C233/83 , C07F5/025 , C07K5/06139 , C07K5/06191
摘要： The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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