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公开(公告)号：EP1309569A2
公开(公告)日：2003-05-14
申请号：EP01973654.5
申请日：2001-08-17
申请人： Millennium Pharmaceuticals, Inc. , KYOWA HAKKO KOGYO CO., LTD. , Pandey, Anjali , Scarborough, Robert M. , Matsuno, Kenji , Ichimura, Michio , Nomoto, Yugi , Fujiwara, Shigeki , Ide, Shinichi , Tsukuda, Eiji , Irie, Junko , Oda, Shoji
发明人： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , FUJIWARA, Shigeki , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
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公开(公告)号：EP1315715A1
公开(公告)日：2003-06-04
申请号：EP01964612.4
申请日：2001-08-17
申请人： Millennium Pharmaceuticals, Inc. , Kyowa Hakko Kogyo Co., Ltd , Pandey, Anjali , Scarborough, Robert M. , Matsuno, Kenji , Ichimura, Michio , Nomoto, Yugi , Ide, Shinichi , Tsukuda, Eiji , Irie, Junko , Oda, Shoji
发明人： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC分类号： C07D403/12 , C07D239/94 , C07D401/12
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
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公开(公告)号：EP1315715B1
公开(公告)日：2008-07-23
申请号：EP01964612.4
申请日：2001-08-17
发明人： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC分类号： C07D403/12 , C07D239/94 , C07D401/12
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
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4.发明授权N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors 有权N-芳基 - {4- [7-（烷氧基）喹唑啉-4-基]哌嗪基}甲酰胺化合物作为PDGF受体阻断剂
公开(公告)号：EP1309569B1
公开(公告)日：2010-10-06
申请号：EP01973654.5
申请日：2001-08-17
发明人： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
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