公开(公告)号：EP1186296A4

公开(公告)日：2004-12-22

申请号：EP00931568

申请日：2000-05-25

申请人： MITSUBISHI PHARMA CORP

发明人： KAWASAKI MASAKAZU ,  GOTOH NOBUHARU ,  HAYASHI YOSHIHARU ,  KAWASAKI KAZUYUKI

IPC分类号： A61K31/4164 ,  A61K31/4174 ,  A61K31/4439 ,  A61P25/28 ,  C07D521/00 ,  C07D233/60 ,  C07D401/06

CPC分类号： C07D249/08 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4439 ,  C07D231/12 ,  C07D233/56

摘要： MAG expression promoters containing compounds represented by general formula (I), optically active isomers thereof or pharmaceutically acceptable salts of the same, wherein each symbol is as defined in the description. As an example of the compounds represented by the general formula (I), 4-[α-hydroxy-5-(1-imidazoyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid may be cited. These MAG expression promoters are useful as preventives and/or remedies for diseases of mammals including humans mainly presenting myelin hypoplasia and, in its turn, myelin sheath hypoplasia or myelin sheath destruction