公开(公告)号：EP1283262A4

公开(公告)日：2004-07-14

申请号：EP01917711

申请日：2001-03-30

申请人： MITSUBISHI PHARMA CORP

发明人： MITSUMORI CRISTINA ,  MORIKAWA NORIYUKI ,  HAYASHI KOJI ,  NAGAHARI KENJI ,  OTA TOSHIO ,  HIO YURI ,  NISHIKAWA TETSUO ,  ISOGAI TAKAO ,  KAWASAKI MASAKAZU ,  HASHIMOTO KENJI ,  KISHIMOTO TOSHIMITSU

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C07K14/48 ,  C12N15/67 ,  C12Q1/02

CPC分类号： C07K14/4705 ,  A61K38/00 ,  G01N2333/48 ,  G01N2500/10

摘要： It is found out that the culture supernatant of COS cells wherein PSEC56 gene is expressed has a neurite outgrowth effect. It is further clarified that this activity of the culture supernatant is brought about by NGF contained therein. Thus, it is found out that PSEC56 is usable as a neurotrophic factor expression-inducing agent and that the induction system of the NGF is applicable to the development of drugs for neural diseases.