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1.发明公开SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY 有权取代的吡啶基具有超氧化物歧化酶活性的PENTAAZAMAKROZYKLE COMPLEX
公开(公告)号：EP1212323A2
公开(公告)日：2002-06-12
申请号：EP00966722.1
申请日：2000-09-14
申请人： MONSANTO COMPANY
发明人： RILEY, Dennis , NEUMANN, William, L. , HENKE, Susan, L. , LENNON, Patrick , ASTON, Karl, W. , SALVEMINI, Daniela , SIKORSKI, James, A. , FOBIAN, Yvette , GRAPPERHAUS, Margaret, L. , KUSTURIN, Carrie, L.
IPC分类号： C07D471/08 , C07D471/06 , A61K31/555 , A61P29/00
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
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2.发明授权SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY 有权取代的吡啶基具有超氧化物歧化酶活性的PENTAAZAMAKROZYKLE COMPLEX
公开(公告)号：EP1212323B1
公开(公告)日：2004-06-09
申请号：EP00966722.1
申请日：2000-09-14
申请人： MONSANTO COMPANY
发明人： RILEY, Dennis , NEUMANN, William, L. , HENKE, Susan, L. , LENNON, Patrick , ASTON, Karl, W. , SALVEMINI, Daniela , SIKORSKI, James, A. , FOBIAN, Yvette , GRAPPERHAUS, Margaret, L. , KUSTURIN, Carrie, L.
IPC分类号： C07D471/08 , C07D471/06 , A61K31/555 , A61P29/00
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
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3.发明公开METHODS OF USE FOR PEROXYNITRITE DECOMPOSITION CATALYSTS, PHARMACEUTICAL COMPOSITIONS THEREFOR 失效使用过亚硝酸盐分解催化剂的方法，药物组合物
公开(公告)号：EP0758892A1
公开(公告)日：1997-02-26
申请号：EP95919143.0
申请日：1995-05-09
申请人： MONSANTO COMPANY
IPC分类号： C07D487 , A61K31 , A61P1 , A61P9 , A61P11 , A61P21 , A61P25 , A61P29 , A61P31 , A61P35 , A61P37 , A61P43 , C07F9 , C07F13 , C07F15
CPC分类号： A61K31/135 , A61K31/28 , A61K31/295 , A61K31/395 , A61K31/40 , A61K31/44 , A61K31/555
摘要： The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe, Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite.
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