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公开(公告)号：EP0116232B1
公开(公告)日：1988-09-07
申请号：EP83307953.6
申请日：1983-12-23
发明人： Hashimoto, Yoshiyuki , Toida, Tomohiro , Sekine, Kazunori , Saito, Minoru , Kawashima, Takuji , Kuboyama, Morio
IPC分类号： C12P1/04
摘要： This invention relates to an antitumor agent comprising as a main ingredient a chemically purified cell walls of microorganisms belonging to genus Bificobacterium having physical integrity of cell wall structure thereof, obtained without being subjected to chemical and/or physical destruction of said cell wall during removal of intracellular substances of said cell, and a process for manufacturing the same, which comprises the steps of; (a) treating said cells with surfactants, (b) treating said cells with proteases, nucleases, organic solvents and dilute acid, to remove intracellular substances out of said cells without destruction thereof, and (c) separating a chemically purified cell walls having physical integrity of cell wall structure thereof.
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公开(公告)号：EP0116232A3
公开(公告)日：1985-09-18
申请号：EP83307953
申请日：1983-12-23
发明人： Hashimoto, Yoshiyuki , Toida, Tomohiro , Sekine, Kazunori , Saito, Minoru , Kawashima, Takuji , Kuboyama, Morio
摘要： This invention relates to an antitumor agent comprising as a main ingredient a chemically purified cell walls of microorganisms belonging to genus Bificobacterium having physical integrity of cell wall structure thereof, obtained without being subjected to chemical and/or physical destruction of said cell wall during removal of intracellular substances of said cell, and a process for manufacturing the same, which comprises the steps of; (a) treating said cells with surfactants, (b) treating said cells with proteases, nucleases, organic solvents and dilute acid, to remove intracellular substances out of said cells without destruction thereof, and (c) separating a chemically purified cell walls having physical integrity of cell wall structure thereof.
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公开(公告)号：EP0116232A2
公开(公告)日：1984-08-22
申请号：EP83307953.6
申请日：1983-12-23
发明人： Hashimoto, Yoshiyuki , Toida, Tomohiro , Sekine, Kazunori , Saito, Minoru , Kawashima, Takuji , Kuboyama, Morio
IPC分类号： C12P1/04
摘要： This invention relates to an antitumor agent comprising as a main ingredient a chemically purified cell walls of microorganisms belonging to genus Bificobacterium having physical integrity of cell wall structure thereof, obtained without being subjected to chemical and/or physical destruction of said cell wall during removal of intracellular substances of said cell, and a process for manufacturing the same, which comprises the steps of; (a) treating said cells with surfactants, (b) treating said cells with proteases, nucleases, organic solvents and dilute acid, to remove intracellular substances out of said cells without destruction thereof, and (c) separating a chemically purified cell walls having physical integrity of cell wall structure thereof.
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