摘要:
Antibiotic TAN-749 or its salts produced by a microorganism belonging to the genus Pseudomonas possess antibacterial activities against gram-positive and gram-negative bacteria including drug-resistant ones, and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.
摘要:
The finding has been made that immunologically related piliated organisms exhibit a hierarchic relationship wherein the cross-reactivity of the antisera to first pili against second pili in the series is greater for the senior members of the series than the cross-reactivity of the first pili with the corresponding antisera from second pili. This asymmetric relationship leads to the situation where the juniormost pili in the series may be utilized to detect the presence of all members of the family senior to it and conversely the seniormost pili may be utilized to protect against infection by all strains junior in the series.
摘要:
A novel strain of Pseudomonas aeruginosa, designated as strain SB-1, is capable of growth on hydrocarbon substrates having 10 to 32 or more carbon atoms, during which growth there is secreted into the culture medium an emulsifier which can be reovered and used for such applications as reducing the viscosity of curde oil in secondary recovery methods, as well as in oil spill management and the cleaning of oil-contaminated vessels and pipelines. A novel mutant strain of P.aeruginosa SB-1, designated SB-3, has the property of growing on solid C 20 +) paraffins but not on liquid alkanes. The selective degradation by strain SB-3 of the solid paraffinic components in crude oil is advantageous in reducing the viscosity of the oil for improving the recovery thereof from oil wells. A novel revertant strain of P.aeruginosa SB-3, designated SB-30, grows both on liquid and solid hydrocarbon substrates, but produces greater amounts of emulsifier than are produced by SB-1 when grown on other relatively inexpensive sources of carbon, such as corn oil or chicken fat.
摘要:
@ The invention provides an antigenic composition substantially free from cells and lipopolysaccharide, the said composition comprising a complex having a polysaccharide constituent and a protein constituent, wherein the polysaccharide constituent comprises capsular polysaccharide specific to serogroup B of N. meningtidis, and the protein constituent comprises N. meningitidis outer-membrane protein selected from the class consisting of those proteins specific to serotype 6, those proteins specific to serotype 2 and having a single dominant component having a molecular weight of 42,000 ± 3,000, and immunological equivalents of such proteins. Preferably the composition also comprises a pharmacologically acceptable metal either as an adjuvant in admixture with the polysaccharide-protein complex, or in complex therewith to provide a triple metal-polysaccharide- protein complex. The composition is useful for the prophylaxis or treatment of bacterial disease in mammals such as man.
摘要:
A novel compound, DC-102, having benzodiazepin nucleus is produced by culturing a microorganism belonging to the genus Streptomyces . It is useful as a medicine because of its antibacterial and anti-tumor activities.
摘要:
A novel substance having vasodilating activity in mammals has a molecular formula of C 21 H 18 O 7 , a molecular weight of 382, an elemental analysis of H: 4.50, C: 65.53 and N: 0, and other defined characteristics. The substance may be produced by fermentation of a microorganism of the genus Micromonospora, preferably the strain Micromonospora sp. K-259 (FERM BP 569).
摘要:
A flocculating agent is produced by growing a micro-organism, e.g. a strain of pseudomonas, in continuous or batch culture under controlled conditions, and the micro-organism thus cultured is allowed or caused to undergo controlled lysis naturally or artificially using heat or a chemical lysing agent. The extent of the lysis is controlled to optimise the production rate and quality of the product agent which may then be stored for use in industrial applications such as water treatment and paper production.
摘要:
The invention relates to a strain of Bacillus thuringiensis , GC 91, a sample of which has been deposited under the accession number NCTC 11821, or a derivative or mutant thereof having entomocidal activity against lepidopterous pests. The invention also relates to a process for producing a strain of Bacillus thuringiensis having improved entomocidal properties by combining into a single strain by plasmid transfer the different entomocidal properties of two respective starting strains. The new strains thus produced are useful in entomicidal compositions.