Determining a hierarchy of piliated organisms and a vaccine prepared from such organisms
    2.
    发明公开
    Determining a hierarchy of piliated organisms and a vaccine prepared from such organisms 失效
    确定引起有机结构的分子和从这些有机体制备的疫苗

    公开(公告)号:EP0049945A3

    公开(公告)日:1982-12-01

    申请号:EP81304120

    申请日:1981-09-09

    摘要: The finding has been made that immunologically related piliated organisms exhibit a hierarchic relationship wherein the cross-reactivity of the antisera to first pili against second pili in the series is greater for the senior members of the series than the cross-reactivity of the first pili with the corresponding antisera from second pili. This asymmetric relationship leads to the situation where the juniormost pili in the series may be utilized to detect the presence of all members of the family senior to it and conversely the seniormost pili may be utilized to protect against infection by all strains junior in the series.

    摘要翻译: 已经发现,发现免疫相关的有丝分裂的生物体具有分级关系,其中该系列的抗血清与第一个皮质相对于第二个皮质的交叉反应性对于该系列的高级成员来说比第一个皮利与 相应的抗血清来自第二刺。 这种不对称关系导致这种情况,其中可以利用系列中的初生性皮质来检测家族的所有成员的存在,反过来,可以利用老年性皮炎来防止该系列中所有初级的所有菌株感染。

    Improved complexes, processes for obtaining them and formulations containing such complexes
    4.
    发明公开
    Improved complexes, processes for obtaining them and formulations containing such complexes 失效
    改进的复合物,用于获得它们的方法和包含这种复合物的制剂

    公开(公告)号:EP0109688A3

    公开(公告)日:1986-12-03

    申请号:EP83111621

    申请日:1983-11-21

    摘要: @ The invention provides an antigenic composition substantially free from cells and lipopolysaccharide, the said composition comprising a complex having a polysaccharide constituent and a protein constituent, wherein the polysaccharide constituent comprises capsular polysaccharide specific to serogroup B of N. meningtidis, and the protein constituent comprises N. meningitidis outer-membrane protein selected from the class consisting of those proteins specific to serotype 6, those proteins specific to serotype 2 and having a single dominant component having a molecular weight of 42,000 ± 3,000, and immunological equivalents of such proteins. Preferably the composition also comprises a pharmacologically acceptable metal either as an adjuvant in admixture with the polysaccharide-protein complex, or in complex therewith to provide a triple metal-polysaccharide- protein complex. The composition is useful for the prophylaxis or treatment of bacterial disease in mammals such as man.

    Flocculating agent
    8.
    发明公开
    Flocculating agent 失效
    絮凝剂

    公开(公告)号:EP0149514A3

    公开(公告)日:1987-07-01

    申请号:EP85300063

    申请日:1985-01-04

    摘要: A flocculating agent is produced by growing a micro-organism, e.g. a strain of pseudomonas, in continuous or batch culture under controlled conditions, and the micro-organism thus cultured is allowed or caused to undergo controlled lysis naturally or artificially using heat or a chemical lysing agent. The extent of the lysis is controlled to optimise the production rate and quality of the product agent which may then be stored for use in industrial applications such as water treatment and paper production.

    摘要翻译: 絮凝剂是通过生长微生物来生产的。 在受控条件下的连续或间歇培养中的假单胞菌菌株和由此培养的微生物被允许或引起自然或人工使用热或化学裂解剂的受控裂解。 控制裂解的过程以优化产品试剂的生产速率和质量,然后将其存储在工业应用中,例如水处理和造纸。