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1.发明公开METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY 有权VERFAHREN UND MATERIALIEN ZUR BEWERTUNG DES VERLUSTS DER HETEROZYGOTIE
公开(公告)号：EP2582847A4
公开(公告)日：2013-12-18
申请号：EP11796544
申请日：2011-06-17
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G06F19/18 , C12Q2537/16
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
摘要翻译： 该文件提供了评估样品（例如癌细胞）中存在杂合性缺失（LOH）特征的方法和材料。 例如，提供了用于确定细胞（例如癌细胞）是否包含LOH标签的方法和材料。 还提供了用于鉴定具有同源性定向修复缺陷（HDR）的细胞（例如癌细胞）的材料和方法，以及用于鉴定可能对特定癌症治疗方案有反应的癌症患者的材料和方法。
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公开(公告)号：EP2794907A4
公开(公告)日：2015-08-26
申请号：EP12860530
申请日：2012-12-21
CPC分类号： C12Q1/6886 , A61K31/282 , A61K33/24 , C12Q2600/106 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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公开(公告)号：EP2721181A4
公开(公告)日：2014-12-31
申请号：EP12801070
申请日：2012-06-15
发明人： GUTIN ALEXANDER , TIMMS KIRSTEN , LANCHBURY JERRY
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q1/6874 , C12Q1/6883 , G06F19/22 , C12Q2535/122 , C12Q2537/143
摘要： Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided.
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公开(公告)号：EP2438197A4
公开(公告)日：2012-11-21
申请号：EP10784236
申请日：2010-06-07
申请人： MYRIAD GENETICS INC
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , G06F19/20
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公开(公告)号：EP3230472A4
公开(公告)日：2018-06-13
申请号：EP15866475
申请日：2015-12-08
申请人： MYRIAD GENETICS INC , TESARO INC
发明人： WILCOXEN KEITH , LANCHBURY JERRY , GUTIN ALEXANDER , TIMMS KIRSTEN , ABKEVICH VICTOR , WANG YAN
IPC分类号： C12Q1/68 , A61K31/416 , G06F19/22
CPC分类号： C12Q1/6886 , A61K31/454 , C12Q2600/106 , C12Q2600/158
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature to predict response to niraparib. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature to predict response to niraparib are provided.
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公开(公告)号：EP3134548A4
公开(公告)日：2018-02-28
申请号：EP15782948
申请日：2015-04-22
申请人： MYRIAD GENETICS INC
发明人： LANCHBURY JERRY , GUTIN ALEXANDER , FLAKE DARL
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574 , G06F19/10
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N2800/52 , G01N2800/54 , G06F19/18 , G06F19/20 , G06F19/24
摘要： The disclosure provides for molecular classification of disease and, particularly, molecular markers for breast cancer prognosis and methods and systems of use thereof.
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