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1.发明公开PRODUCTION OF PROPANOLS, ALCOHOLS, AND POLYOLS IN CONSOLIDATED BIOPROCESSING ORGANISMS 审中-公开茉莉酮丙酮，苯丙醇在康奈尔生物处理有机物中的聚苯乙烯（HONTELLUNG VON PROPANOLEN，ALKOHOLEN UND POLYOLEN IN KONSOLIDIERTEN BIOPROCESSING-ORGANISMEN
公开(公告)号：EP2467490A1
公开(公告)日：2012-06-27
申请号：EP10748027.9
申请日：2010-08-20
申请人： Mascoma Corporation
发明人： MCBRIDE, John , RAJGARHIA, Vineet , SHAW, Arthur J., IV , TRIPATHI, Shital, A. , BREVNOVA, Elena , CAIAZZA, Nicky , VAN DIJKEN, Hans , FROEHLICH, Allan , SILLERS, William, Ryan , FLATT, Jim
CPC分类号： C12P7/18 , C12P7/04 , C12P7/36 , C12P2203/00
摘要： The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, up-regulated or down-regulated.
摘要翻译： 本发明提供了在固体生物处理系统（CBP）中导致丙醇，醇或多元醇形成的新型代谢途径，其中木质纤维素生物质被有效地转化为这样的产物。 更具体地，本发明提供重组微生物，其中微生物表达一种或多种天然和/或异源酶; 其中一种或多种酶在一个或多个工程化代谢途径中起作用以实现：（1）将碳水化合物源转化为1,2-丙二醇，异丙醇，乙醇和/或甘油; （2）将碳水化合物源转化成正丙醇和异丙醇; （3）将碳水化合物源转化成异丙醇和甲醇; 或（4）将碳水化合物源转化成丙二醇和丙酮; 其中所述一种或多种天然和/或异源酶被激活，上调或下调。
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