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1.发明公开Gene knockout mesophilic and thermophilic organisms, and methods of use thereof 审中-公开嗜温和嗜热生物的基因敲除和使用它们的方法
公开(公告)号：EP2511284A2
公开(公告)日：2012-10-17
申请号：EP12164670.7
申请日：2008-05-09
申请人： Mascoma Corporation
CPC分类号： C12P7/10 , C12N9/0006 , C12N9/1029 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/90 , C12N9/92 , C12N15/74 , C12P7/065 , C12P2203/00 , C12Y101/01002 , C12Y101/01027 , C12Y101/02003 , C12Y203/01008 , C12Y207/01017 , C12Y207/02001 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non- native gene encodes a first non-native enzyme involved in the metabolic production of ethanol.; Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
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公开(公告)号：EP2511287A3
公开(公告)日：2012-11-28
申请号：EP12164673.1
申请日：2008-05-09
申请人： Mascoma Corporation
CPC分类号： C12P7/10 , C12N9/0006 , C12N9/1029 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/90 , C12N9/92 , C12N15/74 , C12P7/065 , C12P2203/00 , C12Y101/01002 , C12Y101/01027 , C12Y101/02003 , C12Y203/01008 , C12Y207/01017 , C12Y207/02001 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non- native gene encodes a first non-native enzyme involved in the metabolic production of ethanol.; Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
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3.发明公开Gene knockout mesophilic and thermophilic organisms, and methods of use thereof 审中-公开基因敲除嗜温和嗜热生物体及其使用方法
公开(公告)号：EP2511284A3
公开(公告)日：2012-11-28
申请号：EP12164670.7
申请日：2008-05-09
申请人： Mascoma Corporation
CPC分类号： C12P7/10 , C12N9/0006 , C12N9/1029 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/90 , C12N9/92 , C12N15/74 , C12P7/065 , C12P2203/00 , C12Y101/01002 , C12Y101/01027 , C12Y101/02003 , C12Y203/01008 , C12Y207/01017 , C12Y207/02001 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non- native gene encodes a first non-native enzyme involved in the metabolic production of ethanol.; Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
摘要翻译： 本发明的一个方面涉及遗传修饰的嗜热或嗜温微生物，其中第一天然基因部分，基本上或完全缺失，沉默，失活或下调，该第一天然基因编码参与 代谢产生有机酸或其盐，由此增加所述嗜热或嗜温微生物产生作为发酵产物的乙醇的天然能力。 在某些实施方案中，前述微生物还包含第一非天然基因，该第一非天然基因编码参与乙醇代谢生产的第一非天然酶。 本发明的另一方面涉及将木质纤维素生物质转化成乙醇的方法，其包括使木质纤维素生物质与遗传修饰的嗜热或嗜温微生物接触。
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公开(公告)号：EP2511287A2
公开(公告)日：2012-10-17
申请号：EP12164673.1
申请日：2008-05-09
申请人： Mascoma Corporation
CPC分类号： C12P7/10 , C12N9/0006 , C12N9/1029 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/90 , C12N9/92 , C12N15/74 , C12P7/065 , C12P2203/00 , C12Y101/01002 , C12Y101/01027 , C12Y101/02003 , C12Y203/01008 , C12Y207/01017 , C12Y207/02001 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non- native gene encodes a first non-native enzyme involved in the metabolic production of ethanol.; Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
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