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公开(公告)号：EP3332258B1
公开(公告)日：2020-01-01
申请号：EP16751783.8
申请日：2016-08-05
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公开(公告)号：EP3332029A1
公开(公告)日：2018-06-13
申请号：EP16754049.1
申请日：2016-08-05
CPC分类号： C12Q1/6841 , C12Q1/6806 , G01N1/36 , G01N2001/364
摘要： The invention enables in situ genomic and transcriptomic assessment of nucleic acids to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ genomic and transcriptomic assessment of nucleic in a new process referred to herein as “expansion fluorescent in situ hybridization” (ExFISH).
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公开(公告)号：EP4355906A2
公开(公告)日：2024-04-24
申请号：EP22747163.8
申请日：2022-06-14
申请人： Massachusetts Institute Of Technology , The Broad Institute Inc. , The President and Fellows of Harvard College
发明人： JIANG, Kaiyi , KRAJESKI, Rohan, Neil , ABUDAYYEH, Omar, Osama , GOOTENBERG, Jonathan, S. , ZHANG, Yifan , CHEN, Fei , CHEN, Xi , KOOB, Jeremy, G.
IPC分类号： C12Q1/6825 , C12N9/22 , C12N15/10
CPC分类号： C12Q1/6825 , C12N15/635 , C12N9/78 , C12Y305/04004 , G06N3/123
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公开(公告)号：EP3788146A1
公开(公告)日：2021-03-10
申请号：EP19796763.1
申请日：2019-05-01
申请人： The General Hospital Corporation , The Broad Institute, Inc. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , President And Fellows Of Harvard College
发明人： MACOSKO, Evan , CHEN, Fei , RODRIQUES, Sam , STICKELS, Robert , MARTIN, Carly
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公开(公告)号：EP3108218A2
公开(公告)日：2016-12-28
申请号：EP15751396.1
申请日：2015-02-20
CPC分类号： G01N1/36 , C12Q1/6841 , G01N1/30 , G01N2001/364 , G02B21/0072
摘要： The present invention relates to an enlarged sample of interest for microscopy and methods for enlarging a sample of interest and the optical imaging of a sample of interest with resolution better than the classical microscopy diffraction limit, by synthesizing a swellable polymer network within a sample, it can be physically expanded, resulting in physical magnification.
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公开(公告)号：EP3332258A1
公开(公告)日：2018-06-13
申请号：EP16751783.8
申请日：2016-08-05
摘要： The invention provides a method termed protein retention ExM (proExM), in which proteins, rather than labels, are anchored to the swellable gel, using a cross-linking molecule. This proExM strategy can be used to perform nanoscale imaging of immunostained cells and tissues as well as samples expressing various FPs as fluorescent signals from genetically encoded fluorescent proteins and/or conventional fluorescently labeled secondary antibodies and streptavidin that are directly anchored to the gel are preserved even when subjected to the nonspecific proteolytic digestion.
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公开(公告)号：EP3262702A1
公开(公告)日：2018-01-03
申请号：EP16710042.9
申请日：2016-02-26
发明人： YIN, Huayi , CHEN, Fei , CHUNG, Brice Hoani, Valentin , OUCHI, Takanari , SADOWAY, Donald, Robert
CPC分类号： H01M2/1673 , H01M2/1646 , H01M4/38 , H01M4/382 , H01M4/387 , H01M4/405 , H01M10/399 , H01M2300/0057
摘要： An electrochemical cell includes a negative electrode having a first liquid phase having a first active metal, a positive electrode having a second liquid phase having a second active metal, and a liquid electrolyte having a salt of the first active metal and a salt of the second active metal. The electrochemical cell also includes a bipolar faradaic membrane, disposed between the negative electrode and the positive electrode, having a first surface facing the negative electrode and a second surface facing the positive electrode. The bipolar faradaic membrane is configured to allow cations of the first active metal to pass through and to impede cations of the second active metal from transferring from the positive electrode to the negative electrode and is at least partially formed from a material having an electronic conductivity sufficient to drive faradaic reactions at the second surface with the cations of the positive electrode.
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