公开(公告)号：EP2344186B1

公开(公告)日：2017-04-05

申请号：EP09740580.7

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  ALEXIS, Frank ,  BASTO, Pamela ,  MOSEMAN, Ashley ,  SHI, Jinjun ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/39

CPC分类号： A61K39/00 ,  A61K39/0002 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2760/20234

公开(公告)号：EP2344187A1

公开(公告)日：2011-07-20

申请号：EP09740582.3

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： SHI, Jinjun ,  ALEXIS, Frank ,  IANNACONE, Matteo ,  MOSEMAN, Ashley ,  BASTO, Pamela ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K47/48869 ,  A61K39/00 ,  A61K47/6925 ,  A61K47/6935

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。

公开(公告)号：EP2344186A1

公开(公告)日：2011-07-20

申请号：EP09740580.7

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  ALEXIS, Frank ,  BASTO, Pamela ,  MOSEMAN, Ashley ,  SHI, Jinjun ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K39/00 ,  A61K39/0002 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2760/20234

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing, and using such nanocarriers and pharmaceutical compositions thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统的细胞的组合物和系统。 本发明提供了能够以抗体产生形式引发免疫系统应答的合成纳米载体，其中纳米载体缺乏任何T细胞抗原。 在一些实施方案中，本发明提供了包含免疫特征表面的纳米载体，其提供纳米载体与抗原呈递细胞的高亲和力结合。 本发明提供了包含这种纳米载体的药物组合物。 本发明提供设计，制造和使用这种纳米载体及其药物组合物的方法。

公开(公告)号：EP2344185A1

公开(公告)日：2011-07-20

申请号：EP09741522.8

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： ALEXIS, Frank ,  IANNACONE, Matteo ,  SHI, Jinjun ,  BASTO, Pamela ,  MOSEMAN, Elliott, Ashley ,  VON ANDRIAN, Ulrich ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K9/14 ,  A61K38/20 ,  A61K38/21 ,  A61K39/00 ,  A61K39/0002 ,  A61K39/002 ,  A61K39/05 ,  A61K39/08 ,  A61K39/12 ,  A61K39/39 ,  A61K45/06

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

公开(公告)号：EP2344187B1

公开(公告)日：2017-07-05

申请号：EP09740582.3

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： SHI, Jinjun ,  ALEXIS, Frank ,  IANNACONE, Matteo ,  MOSEMAN, Ashley ,  BASTO, Pamela ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K47/48869 ,  A61K39/00 ,  A61K47/6925 ,  A61K47/6935

公开(公告)号：EP2346528B1

公开(公告)日：2016-04-06

申请号：EP09740581.5

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  VON ANDRIAN, Ulrich ,  FAROKHZAD, Omid, C. ,  ALEXIS, Frank ,  BASTO, Pamela ,  SHI, Jinjun ,  MOSEMAN, Elliott Ashley ,  LANGER, Robert ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K39/00

公开(公告)号：EP2346528A1

公开(公告)日：2011-07-27

申请号：EP09740581.5

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  VON ANDRIAN, Ulrich ,  FAROKHZAD, Omid, C. ,  ALEXIS, Frank ,  BASTO, Pamela ,  SHI, Jinjun ,  MOSEMAN, Elliott Ashley ,  LANGER, Robert ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K39/00

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统的细胞的组合物和系统。 本发明提供了能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含具有多个尼古丁部分的免疫特征表面的纳米载体。 本发明提供了包含纳米载体的药物组合物。 本发明提供设计，制造和使用其纳米载体及其药物组合物的方法。 例如，本发明描述了能够引发免疫应答和产生抗尼古丁抗体的纳米载体。

公开(公告)号：EP2542670A2

公开(公告)日：2013-01-09

申请号：EP11707990.5

申请日：2011-03-07

申请人： President and Fellows of Harvard College

发明人： VON ANDRIAN, Ulrich ,  MALDONADO, Roberto ,  VASCOTTO, Fulvia

IPC分类号： C12N5/0784

CPC分类号： C12N5/0639 ,  A61K35/15 ,  A61K2035/122 ,  A61K2035/124 ,  A61K2039/5154 ,  C12N5/064 ,  C12N2500/30 ,  C12N2500/40 ,  C12N2501/04 ,  C12N2501/052 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2501/70 ,  G01N33/5079

摘要： The invention provides, for example, compositions comprising induced tolerogenic dendritic cells which are capable of suppressing an antigen specific T cell-mediated immune response, and to methods of making and using the same. The invention also provides compositions comprising induced immunogenic dendritic cells and methods of making and using them.