公开(公告)号：EP2217269B1

公开(公告)日：2017-04-12

申请号：EP08839738.5

申请日：2008-10-12

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  The Children's Medical Center Corporation

发明人： VON ANDRIAN, Ulrich, H. ,  FAROKHZAD, Omid, C. ,  LANGER, Robert, S. ,  JUNT, Tobias ,  MOSEMAN, Elliott Ashley ,  ZHANG, Liangfang ,  BASTO, Pamela ,  IANNACONE, Matteo ,  ALEXIS, Frank

IPC分类号： A61K39/00

CPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.

公开(公告)号：EP2144600A2

公开(公告)日：2010-01-20

申请号：EP08745171.2

申请日：2008-04-04

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  The Brigham and Women's Hospital, Inc.

发明人： ALEXIS, Frank ,  ZHANG, Liangfang ,  RADOVIC-MORENO, Aleksandar, F. ,  GU, Frank, X. ,  BASTO, Pamela ,  LEVY-NISSENBAUM, Etgar ,  CHAN, Juliana ,  LANGER, Robert, S. ,  FAROKHZAD, Omid, C.

IPC分类号： A61K9/16

CPC分类号： A61K9/5123 ,  A61K9/5153 ,  A61K9/5192 ,  A61K47/62 ,  A61K47/6935 ,  A61K47/6937 ,  B82Y5/00

摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

公开(公告)号：EP2217269A2

公开(公告)日：2010-08-18

申请号：EP08839738.5

申请日：2008-10-12

申请人： Massachusetts Institute of Technology

发明人： VON ANDRIAN, Ulrich, H. ,  FAROKHZAD, Omid, C. ,  LANGER, Robert, S. ,  JUNT, Tobias ,  MOSEMAN, Ashley ,  ZHANG, Liangfang ,  BASTO, Pamela ,  IANNACONE, Matteo ,  ALEXIS, Frank

IPC分类号： A61K39/00

CPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含疫苗纳米载体的药物组合物。 本发明提供了疫苗纳米载体的设计，制造和使用方法及其药物组合物。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种疫苗纳米载体。