公开(公告)号：EP2344186B1

公开(公告)日：2017-04-05

申请号：EP09740580.7

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  ALEXIS, Frank ,  BASTO, Pamela ,  MOSEMAN, Ashley ,  SHI, Jinjun ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/39

CPC分类号： A61K39/00 ,  A61K39/0002 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2760/20234

公开(公告)号：EP2344187A1

公开(公告)日：2011-07-20

申请号：EP09740582.3

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： SHI, Jinjun ,  ALEXIS, Frank ,  IANNACONE, Matteo ,  MOSEMAN, Ashley ,  BASTO, Pamela ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K47/48869 ,  A61K39/00 ,  A61K47/6925 ,  A61K47/6935

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含免疫表面的纳米载体。 当给予受试者时，纳米载体能够靶向抗原呈递细胞。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明的纳米载体及其药物组合物的方法。

公开(公告)号：EP2344186A1

公开(公告)日：2011-07-20

申请号：EP09740580.7

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  ALEXIS, Frank ,  BASTO, Pamela ,  MOSEMAN, Ashley ,  SHI, Jinjun ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K39/00 ,  A61K39/0002 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2760/20234

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing, and using such nanocarriers and pharmaceutical compositions thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统的细胞的组合物和系统。 本发明提供了能够以抗体产生形式引发免疫系统应答的合成纳米载体，其中纳米载体缺乏任何T细胞抗原。 在一些实施方案中，本发明提供了包含免疫特征表面的纳米载体，其提供纳米载体与抗原呈递细胞的高亲和力结合。 本发明提供了包含这种纳米载体的药物组合物。 本发明提供设计，制造和使用这种纳米载体及其药物组合物的方法。

公开(公告)号：EP2344185A1

公开(公告)日：2011-07-20

申请号：EP09741522.8

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： ALEXIS, Frank ,  IANNACONE, Matteo ,  SHI, Jinjun ,  BASTO, Pamela ,  MOSEMAN, Elliott, Ashley ,  VON ANDRIAN, Ulrich ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K9/14 ,  A61K38/20 ,  A61K38/21 ,  A61K39/00 ,  A61K39/0002 ,  A61K39/002 ,  A61K39/05 ,  A61K39/08 ,  A61K39/12 ,  A61K39/39 ,  A61K45/06

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

公开(公告)号：EP2217269A2

公开(公告)日：2010-08-18

申请号：EP08839738.5

申请日：2008-10-12

申请人： Massachusetts Institute of Technology

发明人： VON ANDRIAN, Ulrich, H. ,  FAROKHZAD, Omid, C. ,  LANGER, Robert, S. ,  JUNT, Tobias ,  MOSEMAN, Ashley ,  ZHANG, Liangfang ,  BASTO, Pamela ,  IANNACONE, Matteo ,  ALEXIS, Frank

IPC分类号： A61K39/00

CPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含疫苗纳米载体的药物组合物。 本发明提供了疫苗纳米载体的设计，制造和使用方法及其药物组合物。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种疫苗纳米载体。

公开(公告)号：EP2344187B1

公开(公告)日：2017-07-05

申请号：EP09740582.3

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： SHI, Jinjun ,  ALEXIS, Frank ,  IANNACONE, Matteo ,  MOSEMAN, Ashley ,  BASTO, Pamela ,  LANGER, Robert ,  FAROKHZAD, Omid, C. ,  VON ANDRIAN, Ulrich ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K47/48869 ,  A61K39/00 ,  A61K47/6925 ,  A61K47/6935

公开(公告)号：EP2217269B1

公开(公告)日：2017-04-12

申请号：EP08839738.5

申请日：2008-10-12

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  The Children's Medical Center Corporation

发明人： VON ANDRIAN, Ulrich, H. ,  FAROKHZAD, Omid, C. ,  LANGER, Robert, S. ,  JUNT, Tobias ,  MOSEMAN, Elliott Ashley ,  ZHANG, Liangfang ,  BASTO, Pamela ,  IANNACONE, Matteo ,  ALEXIS, Frank

IPC分类号： A61K39/00

CPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.

公开(公告)号：EP3074047A2

公开(公告)日：2016-10-05

申请号：EP14812374.8

申请日：2014-11-25

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute Of Technology

发明人： PRIDGEN, Eric, M. ,  ALEXIS, Frank ,  FAROKHZAD, Omid, C. ,  LANGER, Robert, S. ,  BLUMBERG, Richard S.

IPC分类号： A61K47/48 ,  A61P5/38

CPC分类号： A61K47/6931 ,  A61K9/0053 ,  A61K9/50 ,  A61K9/5089 ,  A61K38/28 ,  A61K47/68 ,  A61K47/6849 ,  A61K47/6929 ,  A61K47/6935 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526

摘要： Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to be delivered, where the receptor mediates transcytosis of the nanoparticle into and through the cells. In a preferred embodiment, the targeting moiety is the neonatal Fc receptor. Examples demonstrate Fc-targeted nanoparticles which are actively transported across the intestinal epithelium, providing a route for the oral delivery of nanoparticle encapsulated active agents including peptides such as insulin.

摘要翻译： 提供受体靶向纳米颗粒（R-NP）用于选择性转运入治疗，预防和诊断试剂的靶组织。 R-NP可以包括聚合物颗粒，脂质颗粒，无机颗粒或其组合，其靶向部分选择性地与待传递试剂的细胞上的受体结合，其中受体介导纳米颗粒的转胞吞作用并通过 细胞。 在优选的实施方案中，靶向部分是新生儿Fc受体。 实施例说明了经过肠上皮积极转运的Fc靶向纳米颗粒，提供了用于口服递送纳米颗粒包封的活性剂（包括诸如胰岛素）的途径。

公开(公告)号：EP2346528B1

公开(公告)日：2016-04-06

申请号：EP09740581.5

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  VON ANDRIAN, Ulrich ,  FAROKHZAD, Omid, C. ,  ALEXIS, Frank ,  BASTO, Pamela ,  SHI, Jinjun ,  MOSEMAN, Elliott Ashley ,  LANGER, Robert ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K39/00

公开(公告)号：EP2346528A1

公开(公告)日：2011-07-27

申请号：EP09740581.5

申请日：2009-10-09

申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

发明人： IANNACONE, Matteo ,  VON ANDRIAN, Ulrich ,  FAROKHZAD, Omid, C. ,  ALEXIS, Frank ,  BASTO, Pamela ,  SHI, Jinjun ,  MOSEMAN, Elliott Ashley ,  LANGER, Robert ,  TONTI, Elena

IPC分类号： A61K39/00

CPC分类号： A61K39/00

摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.

摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统的细胞的组合物和系统。 本发明提供了能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供了包含具有多个尼古丁部分的免疫特征表面的纳米载体。 本发明提供了包含纳米载体的药物组合物。 本发明提供设计，制造和使用其纳米载体及其药物组合物的方法。 例如，本发明描述了能够引发免疫应答和产生抗尼古丁抗体的纳米载体。