公开(公告)号：EP2367599A1

公开(公告)日：2011-09-28

申请号：EP09830725.9

申请日：2009-12-02

申请人： Massachusetts Institute of Technology ,  The General Hospital Corporation ,  President and Fellows of Harvard College

发明人： TSAI, Li-Huei ,  FISCHER, Andre ,  HAGGARTY, Stephen ,  TANG, Weiping ,  SCHREIBER, Stuart, L. ,  HOLSON, Edward ,  WAGNER, Florence ,  MOYER, Mikel, P.

IPC分类号： A61P25/00 ,  A61K31/165 ,  C07C235/42

CPC分类号： A61K31/00 ,  A61K9/0085 ,  A61K31/167 ,  A61K31/353 ,  A61K31/381 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/7068 ,  A61K31/7088 ,  A61K31/7105 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDACl/2 or HDACl/2/3.

公开(公告)号：EP2317994A2

公开(公告)日：2011-05-11

申请号：EP09800677.8

申请日：2009-07-23

申请人： Massachusetts Institute of Technology ,  The General Hospital Corporation

发明人： TSAI, Li-Huei ,  HAGGARTY, Stephen ,  KIM, Dohoon

IPC分类号： A61K31/16 ,  C07C259/04

CPC分类号： A61K31/675 ,  A61K31/122 ,  A61K31/16 ,  A61K31/198 ,  A61K31/352 ,  A61K31/366 ,  A61K31/662 ,  C07D223/16 ,  C07D311/30 ,  C07D311/80 ,  C07D493/18

摘要： The invention provides methods and compounds for the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (Amyotrophic Lateral Sclerosis), traumatic brain injury, ischemic brain injury or a stroke. In one aspect the compounds are HDACl activators. Exemplary HDACl activators include metal chelators, iron chelators, deferoxamin, flavonoids, compounds comprising a catechol moity, ginkgetin K, Chembridge 5104434, sciadopilysin, tetrahydrogamboic acid, TAM-11, LY 235959, CGS 19755, SK&F 97541, etidronic acid, levonordefrin, methyldopa, ampicillin trihydrate, D-aspartic acid, gamma-D-glutamylaminomethylsulfonic acid, phenazopyridine hydrochloride, oxalamine citrate salt, podophyllotoxin, SK&F 97541, (+-)-4-amino-3-(5- chloro-2-thienyl)-butanoic acid, (RS)-(tetrazol-5-yl) glycine, R(+)-SKF-81297, gambogic acid, and derivatives thereof.

公开(公告)号：EP2701699A1

公开(公告)日：2014-03-05

申请号：EP12775936.3

申请日：2012-04-30

申请人： The Broad Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital ,  Massachusetts Institute of Technology (MIT)

发明人： HOLSON, Edward ,  WAGNER, Florence, Fevrier ,  WEIWER, Michel ,  TSAI, Li-Huei ,  HAGGARTY, Stephen ,  ZHANG, Yan-Ling

IPC分类号： A61K31/27

摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R 2a , R 2b , R 2c , R 5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

公开(公告)号：EP2701699B1

公开(公告)日：2019-10-16

申请号：EP12775936.3

申请日：2012-04-30

申请人： The Broad Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital ,  Massachusetts Institute of Technology (MIT)

发明人： HOLSON, Edward ,  WAGNER, Florence, Fevrier ,  WEIWER, Michel ,  TSAI, Li-Huei ,  HAGGARTY, Stephen ,  ZHANG, Yan-Ling

IPC分类号： C07D403/12 ,  C07D309/12 ,  A61P35/00 ,  A61K31/38 ,  C07D311/82 ,  A61K31/4523 ,  A61K31/351 ,  A61K31/167 ,  C07D491/107 ,  C07D295/185 ,  C07D401/12 ,  C07D237/04 ,  C07D407/12