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公开(公告)号：EP3253424A1
公开(公告)日：2017-12-13
申请号：EP16711333.1
申请日：2016-02-03
发明人： PATTON, Thomas , BRENNAN, James , STAPLES, Ian , ELDER, Iain , CALLAGHAN, Annette , DRYDEN, Matthew , BARRETT, John, Reginald , KERSHAW, David , SALIB, Rami
CPC分类号： D01F4/00 , A01N25/34 , A01N63/00 , A61K9/70 , A61K38/443 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/38 , A61L15/40 , A61L15/425 , A61L15/44 , A61L15/46 , A61L2300/11 , A61L2300/232 , A61L2300/254 , A61L2300/404 , A61L2400/12 , C12Y101/03004 , D01F9/00 , D10B2509/022 , C08L29/04 , C08L39/04 , C08L71/02
摘要： Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing.
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公开(公告)号：EP3136854A1
公开(公告)日：2017-03-08
申请号：EP14728599.3
申请日：2014-04-30
IPC分类号： A01N37/04 , A01N59/00 , A01N63/02 , A01N65/20 , A23L21/25 , A23B7/154 , A61L15/42 , A61K35/64 , A01P1/00
摘要： Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.
摘要翻译： 描述了用于产生抗微生物活性的储存稳定组合物。 组合物包含能够转化底物以释放过氧化氢的酶，以及包含酶底物的未精制天然物质如蜂蜜。 在某些实施方案中，酶是纯化的酶。 在其它实施方案中，底物缺乏过氧化氢酶活性，并且酶是能够将底物转化成释放可能存在于未精制天然物质中的过氧化氢的任何酶活性的补充。 储存稳定的组合物不包括足够的游离水以使酶转化底物。 描述了组合物用于治疗微生物感染和伤口的用途，以及它们的生产方法。
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公开(公告)号：EP3136854B1
公开(公告)日：2020-03-25
申请号：EP14728599.3
申请日：2014-04-30
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公开(公告)号：EP3324998A1
公开(公告)日：2018-05-30
申请号：EP16745142.6
申请日：2016-07-22
发明人： COX, Sophie Constance , HALL, Thomas Jon , GROVER, Liam Michael , SALIB, Rami , BARRETT, John, Reginald , BRENNAN, James , PATTON, Thomas , STAPLES, Ian
IPC分类号： A61K38/44 , A61K9/00 , A61K47/06 , A61K47/10 , A61K9/10 , A61K35/644 , A61P31/22 , A61P31/04
CPC分类号： A61K38/443 , A61K9/0014 , A61K9/06 , A61K35/644 , A61K47/10 , A61K47/24 , A61K47/44 , A61P31/04 , A61P31/22 , C12Y101/03004
摘要： Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as colloids, suspensions or emulsions, especially as creams or sprays. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections.
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公开(公告)号：EP3223833A1
公开(公告)日：2017-10-04
申请号：EP15804915.5
申请日：2015-11-24
发明人： PATTON, Thomas , BRENNAN, James , STAPLES, Ian , ELDER, Iain , CALLAGHAN, Annette , DRYDEN, Matthew , BARRETT, John, Reginald , KERSHAW, David , SALIB, Rami.
IPC分类号： A61K35/644 , A61P17/02
CPC分类号： A61K35/644 , A61K38/443 , C12N9/0006 , C12Y101/03004 , A61K38/44
摘要： Compositions for prevention and treatment of microbial infectious, such as microbial infections that comprise a biofilm, or a microbe that is capable of forming a biofilm are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide and a substance that includes a substrate for the enzyme. The enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the substance. The substance may be an unrefined natural substance or a substance that includes a purified substrate for the enzyme.
摘要翻译： 描述了用于预防和治疗微生物感染的组合物，例如包含生物膜的微生物感染或能够形成生物膜的微生物。 该组合物包含能够转化底物以释放过氧化氢的酶和包含该酶底物的物质。 该酶是任何能够转化底物以释放可能存在于物质中的过氧化氢的酶活性的附加物。 该物质可以是未精制的天然物质或包含酶的纯化底物的物质。
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公开(公告)号：EP3253424B1
公开(公告)日：2020-12-09
申请号：EP16711333.1
申请日：2016-02-03
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公开(公告)号：EP3223833B1
公开(公告)日：2019-05-15
申请号：EP15804915.5
申请日：2015-11-24
发明人： PATTON, Thomas , BRENNAN, James , STAPLES, Ian , ELDER, Iain , CALLAGHAN, Annette , DRYDEN, Matthew , BARRETT, John, Reginald , KERSHAW, David , SALIB, Rami.
IPC分类号： A61K35/644 , A61P17/02
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公开(公告)号：EP3245871A1
公开(公告)日：2017-11-22
申请号：EP17181068.2
申请日：2014-04-30
IPC分类号： A01N37/04 , A01N59/00 , A01N63/02 , A01N65/20 , A23B7/154 , A61L15/42 , A61K35/64 , A01P1/00
CPC分类号： A01N63/00 , A01N59/00 , A01N63/02 , A01N65/00 , A23L21/25 , A23L29/06 , A23L33/10 , A61K35/644 , A61K38/443 , A61L15/38 , A61L15/40 , A61L15/46 , A61L2300/254 , A61L2300/404 , C12Y101/03004 , A01N65/20 , A61K2300/00
摘要： Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and a substance that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.
摘要翻译： 描述了用于产生抗微生物活性的储存稳定的组合物。 该组合物包含能够转化底物以释放过氧化氢的酶，以及包含酶底物的物质。 在某些实施方案中，酶是纯化的酶。 储存稳定的组合物不包含足够的游离水以允许酶转化底物。 描述了使用这些组合物来治疗微生物感染和伤口，以及它们的生产方法。
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