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8 条记录 (耗时 0.014 秒)

    Multiple target T cell receptor
    7.
    发明公开
    Multiple target T cell receptor 有权
    Mehrfachziel-T-Zellen-Rezeptor

    公开(公告)号：EP2258720A1

    公开(公告)日：2010-12-08

    申请号：EP10163251.1

    申请日：2010-05-19

    申请人： Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch;

    发明人： Kieback, Elisa ,  Charo, Jehad ,  Blankenstein, Thomas ,  Uckert, Wolfgang ,  Perez, Cynthia

    IPC分类号： C07K14/705 ,  C12N15/62 ,  A61K38/17 ,  A61P35/00

    CPC分类号： C07K14/7051 ,  A61K38/00 ,  C07K2319/33

    摘要： The present invention is directed to a functional T cell receptor (TCR) fusion protein (TFP) recognizing and binding to at least one MHC-presented epitope, and containing at least one amino acid sequence recognizing and binding an antigen. The present invention is further directed to an isolated nucleic acid molecule encoding the same, a T cell expressing said TFP, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.

    摘要翻译： 本发明涉及识别和结合至少一个MHC呈递的表位并且含有至少一个识别和结合抗原的氨基酸序列的功能性T细胞受体（TCR）融合蛋白（TFP）。 本发明还涉及编码该分离的核酸分子，表达所述TFP的T细胞和用于治疗涉及表达所述肿瘤相关抗原的恶性细胞的疾病的药物组合物。

    T cell line-based packaging cell line for the production of retroviruses by enriching of CD3 expressing cells
    8.
    发明公开
    T cell line-based packaging cell line for the production of retroviruses by enriching of CD3 expressing cells 审中-公开
    基于T细胞的包装细胞，用于通过富集CD3表达细胞生产反转录病毒的

    公开(公告)号：EP1739180A1

    公开(公告)日：2007-01-03

    申请号：EP05013833.8

    申请日：2005-06-27

    申请人： Max-Delbrück-Centrum für Molekulare Medizin (MDC)

    发明人： Uckert, Wolfgang ,  Blankenstein, Thomas

    IPC分类号： C12N15/867 ,  C12N5/06 ,  C12N5/10

    CPC分类号： C12N7/00 ,  A01K2217/05 ,  C07K14/7051 ,  C12N5/0636 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/13052 ,  C12N2810/6054

    摘要： The present invention relates to retroviral vector systems, in particular the development of packaging or helper cell lines that are based on T cells and that are suitable for producing T cell receptor retroviruses. Thereby, the present invention relates to T cell line specific retroviral expression vectors, and mammalian T cell line-based helper cell lines. The invention further relates to methods for expressing transgenes and to T cell line specific retroviral vector systems, including biochemical kits, that utilize and/or comprise the T cell line specific retroviral expression vectors and/or mammalian T cell line-based helper cell lines.

    摘要翻译： 本发明涉及反转录病毒载体系统，特别是包装或辅助细胞系的开发并基于T细胞和确实适合于生产的T细胞受体的逆转录病毒。 由此，本发明涉及T细胞系特异性逆转录病毒表达载体，和哺乳动物T细胞系为基础的辅助细胞系。 本发明还涉及到用于表达的转基因和T细胞系特异性的逆转录病毒载体系统的方法，包括生化试剂盒，并使用和/或包含T细胞系特异性逆转录病毒表达载体和/或哺乳动物T细胞系为基础的辅助细胞系。