公开(公告)号：EP3362090A1

公开(公告)日：2018-08-22

申请号：EP16781446.6

申请日：2016-10-13

申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft

发明人： BLANKENSTEIN, Thomas ,  WILLIMSKY, Gerald

IPC分类号： A61K39/12 ,  C07K14/725 ,  C07K14/005 ,  C12N5/0783 ,  C07K16/08 ,  A61K39/00

CPC分类号： C07K16/08 ,  A61K39/12 ,  A61K2039/523 ,  A61P31/20 ,  C07K14/005 ,  C07K14/7051 ,  C07K2318/00 ,  C12N5/0636 ,  C12N2510/00 ,  C12N2710/20034

摘要： The present disclosure pertains to novel high avidity antigen recognizing constructs against Human Papilloma Virus antigens. The invention provides novel T cell receptor (TCR) based molecules which are selective and specific for HPV 16/18 proteins E5, E6 and E7. The TCR of the invention, and HPV antigen-binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of HPV infection, as well as for the diagnosis, treatment and prevention of HPV infection mediated secondary diseases as HPV infection caused cancers, such as cervical, nasopharyngeal or head and neck cancer. Further provided are nucleic acids encoding the proteins of the invention, and recombinant cells expressing the same.

公开(公告)号：EP4323389A1

公开(公告)日：2024-02-21

申请号：EP22716273.2

申请日：2022-04-14

申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft ,  Charité - Universitätsmedizin Berlin

发明人： BLANKENSTEIN, Thomas ,  WILLIMSKY, Gerald

IPC分类号： C07K14/47 ,  A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C12N5/0783 ,  C07K14/705

公开(公告)号：EP4067371A1

公开(公告)日：2022-10-05

申请号：EP21166438.8

申请日：2021-03-31

申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft ,  Charité - Universitätsmedizin Berlin

发明人： BLANKENSTEIN, Thomas ,  THIEDE, Katerina ,  WILLIMSKY, Gerald

IPC分类号： C07K14/435

摘要： The invention is based on antigen binding proteins (ABPs) such as T-cell receptors (TCR) expressed on T-cells, which have a specificity to bind to MHC presented Hepatitis C Virus peptides. Provided are isolated ABPs as well as genetic constructs expressing the ABPs, recombinant host cells harboring the ABP of the invention and methods for producing such ABPs and host cells. Moreover, provided are medical applications involving the TCR of the invention, for example in context of an adoptive T-cell therapy.

公开(公告)号：EP3731861A1

公开(公告)日：2020-11-04

申请号：EP19700444.3

申请日：2019-01-02

申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft ,  Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts ,  Imperial College Innovations Limited ,  Charité - Universitätsmedizin Berlin

发明人： BLANKENSTEIN, Thomas ,  WILLIMSKY, Gerald ,  LIEPE, Juliane ,  KLOETZEL, Peter, Michael ,  MISHTO, Michele ,  BEIER, Christin

IPC分类号： A61K39/00 ,  A61K48/00 ,  A61K38/00 ,  A61K35/17 ,  C07K16/32