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公开(公告)号：EP1786572B1
公开(公告)日：2009-03-11
申请号：EP05782590.3
申请日：2005-09-12
发明人： GRÄTER, Stefan
CPC分类号： B82Y30/00 , A61K47/6957 , A61L27/02 , A61L27/60 , A61L31/02 , B29C33/0016 , B29C33/12 , B29C41/20 , B82Y5/00 , Y10S977/887 , Y10S977/89 , Y10S977/891 , Y10S977/892 , Y10T428/249921
摘要： The invention relates to a method for production of a surface-structured substrate, comprising the steps: (i) production of a first substrate, nanostructured with inorganic nanoclusters on at least one surface, (ii) application of a substrate material for a second substrate, different from the first material to the nanostructured surface of the first substrate as obtained in step (i) and (iii) separation of the first substrate from the second substrate of step (ii), including the inorganic nanoclusters to give a second substrate nanostructured with the nanoclusters. The invention further relates to a surface-structured substrate obtained by said method and the use of the surface-structured substrate for application to a stent or implant material for the adhesion of cells, viruses and/or bacteria and the serum-free culture of cells, for example, for skin replacement and, furthermore, all applications of said substrate in which biological systems can be imitated, modified, examined or quantified by the structured application of biologically-active molecules and the application thereof in optical or electronic components and chemical and biological sensor systems..
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2.发明公开
公开(公告)号：EP1986951A1
公开(公告)日：2008-11-05
申请号：EP07703470.0
申请日：2007-02-14
发明人： SPATZ, Joachim , GRÄTER, Stefan
IPC分类号： B81C1/00
CPC分类号： B81C1/00206 , B29C59/025 , Y10T428/24479
摘要： A method for producing a patterned surface (10), which has a multiplicity of filamentary projections (11), comprises the steps of bringing a stamp face (21.1, 21.2) and a pattern face (31.1, 31.2) into contact with each other, at least one or the other, the stamp face (21.1, 21.2) or the pattern face (31.1, 31.2), having a flowable substance (20), movement to separate the stamp face (21.1, 21.2) and the pattern face (31.1, 31.2), wherein connecting filament strands (22) of the flowable substance (20) are drawn between the stamp face (21.1, 21.2) and the pattern face (31.1, 31.2), and interruption of the connecting filament strands (22), so that the filamentary projections (11) are formed on at least one or the other, the stamp face (21.1, 21.2) or the pattern face (31.1, 31.2). Devices (100) that are produced by this method are described.
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公开(公告)号：EP1786572A1
公开(公告)日：2007-05-23
申请号：EP05782590.3
申请日：2005-09-12
发明人： GRÄTER, Stefan
CPC分类号： B82Y30/00 , A61K47/6957 , A61L27/02 , A61L27/60 , A61L31/02 , B29C33/0016 , B29C33/12 , B29C41/20 , B82Y5/00 , Y10S977/887 , Y10S977/89 , Y10S977/891 , Y10S977/892 , Y10T428/249921
摘要： The invention relates to a method for production of a surface-structured substrate, comprising the steps: (i) production of a first substrate, nanostructured with inorganic nanoclusters on at least one surface, (ii) application of a substrate material for a second substrate, different from the first material to the nanostructured surface of the first substrate as obtained in step (i) and (iii) separation of the first substrate from the second substrate of step (ii), including the inorganic nanoclusters to give a second substrate nanostructured with the nanoclusters. The invention further relates to a surface-structured substrate obtained by said method and the use of the surface-structured substrate for application to a stent or implant material for the adhesion of cells, viruses and/or bacteria and the serum-free culture of cells, for example, for skin replacement and, furthermore, all applications of said substrate in which biological systems can be imitated, modified, examined or quantified by the structured application of biologically-active molecules and the application thereof in optical or electronic components and chemical and biological sensor systems..
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