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公开(公告)号：EP2684873B1
公开(公告)日：2019-01-16
申请号：EP13176579.4
申请日：2009-06-09
申请人： Ludwig-Maximilians-Universität München , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Giese, Armin , Bertsch, Uwe , Kretzschmar, Hans , Habeck, Matthias , Hirschberger, Thomas , Tavan, Paul , Griesinger, Christian , Leonov, Andrei , Ryazanov, Sergey , Frick, Petra , Geissen, Markus , Groschup, Martin, H. , Wagner, Jens
IPC分类号： C07D231/06 , C07D231/12 , C07D233/22 , C07D261/08 , C07D271/06 , C07D405/04 , C07D207/333 , A61K31/415 , A61P25/28
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2.发明公开Drugs for inhibiting aggregation of proteins invoved in diseases linked to protein aggregation and/or neurodegenerative diseases 审中-公开药物，以抑制蛋白在疾病的聚合是与蛋白聚集和/或神经变性疾病
公开(公告)号：EP2687513A1
公开(公告)日：2014-01-22
申请号：EP13176577.8
申请日：2009-06-09
申请人： Ludwig-Maximilians-Universität München , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Giese, Armin , Bertsch, Uwe , Kretzschmar, Hans , Habeck, Mathias , Hirschberger, Thomas , Tavan, Paul , Griesinger, Christian , Leonov, Andrei , Ryazanov, Sergey , Frick, Petra , Geissen, Markus , Groschup, Martin, H. , Wagner, Jens
IPC分类号： C07D231/06 , C07D231/12 , C07D233/22 , C07D261/08 , C07D271/06 , C07D405/04 , C07D207/333 , A61K31/415 , A61P25/28
CPC分类号： C07D231/12 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/42 , A61K31/4245 , C07D207/333 , C07D231/06 , C07D233/64 , C07D261/08 , C07D271/06 , C07D405/04 , C07D413/04 , G01N33/6896 , G01N2800/2828
摘要： The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.
摘要翻译： 本发明涉及由式（E）表示的化合物。 因此，本发明涉及用于治疗或预防与蛋白聚集和/或神经变性疾病的疾病使用由式（E）表示的化合物。 更过地，本发明涉及药物和诊断组合物包括本发明的化合物以及一种试剂盒。 进一步地，本发明涉及聚集蛋白的成像沉积物的方法。 因此，一种制备本发明的可检测标记的化合物的试剂盒是游离缺失盘。
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公开(公告)号：EP4173485A1
公开(公告)日：2023-05-03
申请号：EP21205130.4
申请日：2021-10-27
IPC分类号： A01N43/50 , A01N43/56 , A01N43/653 , A01N43/76 , A01N43/80 , A01N43/82 , A01P1/00 , A01P3/00 , C07D231/12 , C07D233/58 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06
摘要： The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like beta-amyloid proteins, that can be important parts of extracellular structures, for example cell walls, adhesion structures to biological surfaces and other pathogenicity related infection structures. This invention discloses that the compound of the formula (I) interferes with the aggregation of such proteins and thus reduce plant pathogen growth significantly.
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公开(公告)号：EP2687513B1
公开(公告)日：2020-12-02
申请号：EP13176577.8
申请日：2009-06-09
申请人： Ludwig-Maximilians-Universität München , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Giese, Armin , Bertsch, Uwe , Kretzschmar, Hans , Habeck, Matthias , Hirschberger, Thomas , Tavan, Paul , Griesinger, Christian , Leonov, Andrei , Ryazanov, Sergey , Frick, Petra , Geissen, Markus , Groschup, Martin, H. , Wagner, Jens
IPC分类号： C07D231/06 , C07D231/12 , C07D233/22 , C07D261/08 , C07D271/06 , C07D405/04 , C07D207/333 , A61K31/415 , A61P25/28
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5.发明公开DRUGS FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES 审中-公开药物蛋白质来抑制聚集疾病的蛋白质聚集和/或相关神经退行性疾病
公开(公告)号：EP2684873A1
公开(公告)日：2014-01-15
申请号：EP13176579.4
申请日：2009-06-09
申请人： Ludwig-Maximilians-Universität München , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Giese, Armin , Bertsch, Uwe , Kretzschmar, Hans , Habeck, Mathias , Hirschberger, Thomas , Tavan, Paul , Griesinger, Christian , Leonov, Andrei , Ryazanov, Sergey , Frick, Petra , Geissen, Markus , Groschup, Martin, H. , Wagner, Jens
IPC分类号： C07D231/06 , C07D231/12 , C07D233/22 , C07D261/08 , C07D271/06 , C07D405/04 , C07D207/333 , A61K31/415 , A61P25/28
CPC分类号： C07D231/12 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/42 , A61K31/4245 , C07D207/333 , C07D231/06 , C07D233/64 , C07D261/08 , C07D271/06 , C07D405/04 , C07D413/04 , G01N33/6896 , G01N2800/2828
摘要： The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.
摘要翻译： 本发明涉及由式（E）表示的化合物。 因此，本发明涉及用于治疗或预防与蛋白聚集和/或神经变性疾病的疾病使用由式（E）表示的化合物。 更过地，本发明涉及药物和诊断组合物包括本发明的化合物以及一种试剂盒。 进一步地，本发明涉及聚集蛋白的成像沉积物的方法。 因此，一种制备本发明的可检测标记的化合物的试剂盒是游离缺失盘。
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