公开(公告)号：EP3529273A1

公开(公告)日：2019-08-28

申请号：EP17861658.7

申请日：2017-10-16

申请人： MedImmune, LLC ,  Humabs Biomed SA

发明人： WANG, Qun ,  STOVER, Charles K. ,  PENNINI, Meghan ,  CHANG, Chew-Shun ,  XIAO, Xiaodong ,  HILLIARD, Jamese ,  KAPLAN, Gilad ,  CORTI, Davide ,  CAMERONI, Elisabetta ,  BELTRAMELLO, Martina

IPC分类号： C07K16/12 ,  A61K39/395 ,  A61K39/40

公开(公告)号：EP3640338A1

公开(公告)日：2020-04-22

申请号：EP19211610.1

申请日：2013-11-06

申请人： MedImmune, LLC

发明人： SELLMAN, Bret ,  TKACZYK, Christine ,  CHOWDHURY, Partha, S. ,  HUA, Lei ,  PAVLIK, Peter ,  BUONPANE, Rebecca ,  CHANG, Chew-Shun

IPC分类号： C12P21/08 ,  A61K39/40 ,  G01N33/554 ,  A61K39/00 ,  C07K16/12 ,  A61K45/06 ,  G01N33/569

摘要： Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

公开(公告)号：EP2917360A2

公开(公告)日：2015-09-16

申请号：EP13852597.7

申请日：2013-11-06

申请人： MedImmune, LLC

发明人： SELLMAN, Bret ,  TKACZYK, Christine ,  CHOWDHURY, Partha, S. ,  HUA, Lei ,  PAVLIK, Peter ,  BUONPANE, Rebecca ,  CHANG, Chew-Shun

IPC分类号： C12P21/08 ,  A61K39/40 ,  G01N33/554

摘要： Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

摘要翻译： 公开了针对金黄色葡萄球菌（金黄色葡萄球菌）表面决定簇抗原和分泌毒素的抗体及其抗原结合片段。 还提供了使用抗体及其抗原结合片段检测，诊断和处理金黄色葡萄球菌的方法。

公开(公告)号：EP2917360B1

公开(公告)日：2020-01-08

申请号：EP13852597.7

申请日：2013-11-06

申请人： MedImmune, LLC

发明人： SELLMAN, Bret ,  TKACZYK, Christine ,  CHOWDHURY, Partha, S. ,  HUA, Lei ,  PAVLIK, Peter ,  BUONPANE, Rebecca ,  CHANG, Chew-Shun

IPC分类号： C12P21/08 ,  A61K39/40 ,  G01N33/554 ,  A61K39/00 ,  C07K16/12 ,  A61K45/06 ,  G01N33/569

公开(公告)号：EP3341004A1

公开(公告)日：2018-07-04

申请号：EP16839995.4

申请日：2016-08-23

申请人： Medimmune, LLC

发明人： WANG, Qun ,  RAJAN, Saravanan ,  CHANG, Chew-Shun ,  HEIDBRINK THOMPSON, Jenny ,  LIN, Hung-Yu ,  STOVER, Charles Kendall ,  PENNINI, Meghan ,  DALL'ACQUA, William ,  CHOWDHURY, Partha S. ,  XIAO, Xiaodong

IPC分类号： A61K38/00 ,  A61K39/108 ,  A61K39/395 ,  C07K14/26 ,  C07K16/12 ,  C07K16/18

CPC分类号： C07K16/1228 ,  A61K39/0266 ,  A61K2039/545 ,  A61K2039/55566 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure provides MrkA binding proteins, e.g., antibodies or antigen binding fragments thereof that bind to MrkA and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae). The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering MrkA binding proteins, e.g., antibodies or antigen-binding fragments thereof, MrkA polypeptides, immunogenic fragments thereof, or polynucleotides encoding MrkA or immunogenic fragments thereof to the subject.