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公开(公告)号：EP3107937A1
公开(公告)日：2016-12-28
申请号：EP15752581.7
申请日：2015-02-20
申请人： MedImmune, LLC , Medimmune Limited
发明人： CELESTE, Anthony , CHODORGE, Matthieu , BUCHANAN, Andrew , RONDINONE, Cristina , GRIMSBY, Joseph , RAVN, Peter , SEAMAN, Jonathan , FAIRMAN, David
CPC分类号： C07K16/40 , A61K38/00 , A61K38/26 , A61K39/00 , A61K39/3955 , A61K2039/505 , C07K14/605 , C07K2317/24 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： This application provides anti-PCSK9~GLP-1 fusions and methods for use.
摘要翻译： 此应用程序提供抗PCSK9〜GLP-1融合和使用方法。
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公开(公告)号：EP3596125A1
公开(公告)日：2020-01-22
申请号：EP18714185.8
申请日：2018-03-16
申请人： Medimmune Limited
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公开(公告)号：EP3495380A1
公开(公告)日：2019-06-12
申请号：EP18182274.3
申请日：2013-12-10
申请人： MedImmune Limited
发明人： AGORAM, Balaji , ANTONSSON, Elise, Madeleine , BEDNAREK, Maria, A , BURMEISTER, Nicole , BENTHEM, Lambertus , FAIRMAN, David , FRITSCH-FREDIN, Maria , JACKSON, Ronald Henry , LOFMARK, Rasmus Jansson , METCALFE, Jaqueline
IPC分类号： C07K14/435
摘要： The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides.
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公开(公告)号：EP3656398A1
公开(公告)日：2020-05-27
申请号：EP19191552.9
申请日：2014-09-11
申请人： MedImmune Limited
发明人： NARWAL, Rajesh , FAIRMAN, David , ROBBINS, Paul , LIANG, Meina , SCHNEIDER, Amy , CHAVEZ, Carlos , HERL, Carina , PAK, Min , LU, Hong , REBELATTO, Marlon , STEELE, Keith , BOUTRIN, Anmarie , SHI, Li , HONG, Shengyan , HIGGS, Brandon , ROSKOS, Lorin
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30
摘要： Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.
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公开(公告)号：EP3043816B1
公开(公告)日：2019-08-14
申请号：EP14766962.6
申请日：2014-09-11
申请人： MedImmune Limited
发明人： NARWAL, Rajesh , FAIRMAN, David , ROBBINS, Paul , LIANG, Meina , SCHNEIDER, Amy , CHAVEZ, Carlos , HERL, Carina , PAK, Min , LU, Hong , REBELATTO, Marlon , STEELE, Keith , BOUTRIN, Anmarie , SHI, Li , HONG, Shengyan , HIGGS, Brandon , ROSKOS, Lorin
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30
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公开(公告)号：EP2931745B1
公开(公告)日：2018-08-22
申请号：EP13849992.6
申请日：2013-12-10
申请人： MedImmune Limited
发明人： AGORAM, Balaji , ANTONSSON, Madeleine , BEDNAREK, Maria , BURMEISTER, Nicole , BENTHEM, Lambertus , FAIRMAN, David , FRITSCH-FREDIN, Maria , JACKSON, Ronald , LOFMARK, Rasmus, Jansson , METCALFE, Jacqueline
IPC分类号： C07K14/435
CPC分类号： C07K14/605 , A61K38/00
摘要： This disclosure provides GLP-1/glue agon agonist peptides for the treatment of metabolic diseases, e.g., obesity.
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7.发明公开
公开(公告)号：EP3043816A1
公开(公告)日：2016-07-20
申请号：EP14766962.6
申请日：2014-09-11
申请人： Medimmune Limited
发明人： NARWAL, Rajesh , FAIRMAN, David , ROBBINS, Paul , LIANG, Meina , SCHNEIDER, Amy , CHAVEZ, Carlos , HERL, Carina , PAK, Min , LU, Hong , REBELATTO, Marlon , STEELE, Keith , BOUTRIN, Anmarie , SHI, Li , HONG, Shengyan , HIGGS, Brandon , ROSKOS, Lorin
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2827 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K16/3023 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/94 , G01N33/57492 , G01N2333/70532
摘要： Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.
摘要翻译： 本文提供了治疗B7-H1表达肿瘤的方法，其包括施用有效量的MEDI4736或其抗原结合片段。
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8.发明公开GLUCAGON/GLP-1 AGONISTS FOR THE TREATMENT OF OBESITY 审中-公开GLUCAGON / GLP-1-AGONISTEN ZUR BEHANDLUNG VON ADIPOSITAS
公开(公告)号：EP2931745A2
公开(公告)日：2015-10-21
申请号：EP13849992.6
申请日：2013-12-10
申请人： MedImmune Limited
发明人： AGORAM, Balaji , ANTONSSON, Madeleine , BEDNAREK, Maria , BURMEISTER, Nicole , BENTHEM, Lambertus , FAIRMAN, David , FRITSCH-FREDIN, Maria , JACKSON, Ronald , LOFMARK, Rasmus, Jansson , METCALFE, Jacqueline
IPC分类号： C07K14/435
CPC分类号： C07K14/605 , A61K38/00
摘要： This disclosure provides GLP-1/glue agon agonist peptides for the treatment of metabolic diseases, e.g., obesity.
摘要翻译： 本公开提供了用于治疗代谢疾病例如肥胖症的GLP-1 /胶激动剂激动剂肽。
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