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    PYRROLOBENZODIAZEPINES
    3.
    发明公开
    PYRROLOBENZODIAZEPINES 审中-公开

    公开(公告)号：EP3408267A1

    公开(公告)日：2018-12-05

    申请号：EP17702066.6

    申请日：2017-01-26

    申请人： Medimmune Limited

    发明人： HOWARD, Philip Wilson ,  CAILLEAU, Thaïs

    IPC分类号： C07D403/12 ,  A61K31/5517 ,  A61P35/00

    CPC分类号： C07D403/12

    摘要： A compound with the formula I, wherein R2 is of formula ΙI, where A is a C5-7 aryl group, X is selected from the group consisting of: OH, SH, CO2H, COH, N=C=0, NHNH2, CONHNH2, (III), (IV), and NHRN, wherein RN is selected from H and C1-4 alkyl, and either: (i) Q1 is a single bond, and Q2 is selected from a single bond and -Z-(CH2)n-, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Q1 is -CH=CH-, and Q2 is a single bond;and its conjugates.

    PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    6.
    发明公开
    PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF 审中-公开
    吡咯并苯并二氮杂及其偶联物

    公开(公告)号：EP3193940A1

    公开(公告)日：2017-07-26

    申请号：EP14777539.9

    申请日：2014-09-10

    申请人： Medimmune Limited

    发明人： HOWARD, Philip Wilson

    IPC分类号： A61K47/50 ,  C07D487/04 ,  A61P35/00

    CPC分类号： A61K47/6851 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6855 ,  C07D487/04 ,  C07D519/00

    摘要： A conjugate of formula (A): Wherein Y is selected from formulae A1 and A2: Z1 is a C1-3 alkylene group; Z2 is a C1-3 alkylene group; Q is: where QX is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue; L is a linker connected to a cell binding agent; CBA is the cell binding agent; and n is an integer between 0 and 48.

    摘要翻译： 式（A）的结合物：其中Y选自结构式A1和A2：Z 1是C 1-3亚烷基; Z2是C1-3亚烷基; Q是：其中QX使得Q是氨基酸残基，二肽残基或三肽残基; L是与细胞结合剂连接的接头; CBA是细胞结合剂; 并且n是0和48之间的整数。