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1.发明公开RECOMBINANT PARAINFLUENZA VIRUS EXPRESSION SYSTEMS AND VACCINES COMPRISING HETEROLOGOUS ANTIGENS DERIVED FROM METAPNEUMOVIRUS 审中-公开反义寡核苷酸表达突变体在IMPFSTOFFE MIT AUS METAPNEUMOVIRUS STAMMENDEN HETEROLOGEN ANTIGENEN
公开(公告)号：EP1485468A2
公开(公告)日：2004-12-15
申请号：EP03716118.9
申请日：2003-02-21
发明人： HALLER, Aurelia , TANG, Roderick , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, Dominicus, M.
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： The present invention relates to recombinant bovine parainfluenza virus (BPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（BPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。
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2.发明公开METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS FOR PROPAGATING VIRUS 审中-公开偏肺病毒菌株和它们在疫苗制剂，并作为为VIRUSPROPAGIERUNG表达抗原序列和方法向量
公开(公告)号：EP1623006A2
公开(公告)日：2006-02-08
申请号：EP04750614.2
申请日：2004-04-23
发明人： HALLER, Aurelia , TANG, Roderick , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, Dominicus, Marcellinus, E.
IPC分类号： C12N1/00
CPC分类号： C07K16/1027 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/505 , A61K2039/543 , A61K2039/544 , A61K2039/70 , C07K14/005 , C07K2317/21 , C07K2317/23 , C12N7/00 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18534 , G01N2333/115
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.
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3.发明公开METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTOR FOR EXPRESSION OF ANTIGENIC SEQUENCES 审中-公开METAPNEUMOVIRUSSTÄMME和它们在疫苗制剂，并作为载体表达抗原序列
公开(公告)号：EP1576090A2
公开(公告)日：2005-09-21
申请号：EP03716116.3
申请日：2003-02-21
发明人： HALLER, Aurelia , TANG, Roderick , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus D.M.E.
IPC分类号： C12N1/00
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , A61K2039/58 , A61K2039/70 , A61K2123/00 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2710/22034 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18522 , C12N2760/18534 , C12N2760/18621 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5088 , G01N33/56983 , G01N2333/08 , Y02A90/26
摘要： The present invention relates to recombinant bovine parainfluenza virus (BPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及一种可用于表达异源基因产物在适当的宿主细胞的系统和/或抢救负海滩RNA的重组病毒没有明示，封装和/或呈现所述异源重组牛副流感病毒（BPIV）cDNA或RNA 基因产物。 特别是异源基因产物包括PIV的或从另一个负海滩RNA病毒另一个物种的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人类偏肺病毒和禽类肺。 嵌合病毒和表达产物可以有利地在疫苗式蒸发散包括对范围广泛的病原体和抗原的疫苗一起使用。
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4.发明公开RECOMBINANT PARAINFLUENZA VIRUS EXPRESSION SYSTEMS AND VACCINES COMPRISING HETEROLOGOUS ANTIGENS DERIVED FROM METAPNEUMOVIRUS 审中-公开重组的包含流感病毒表达系统的疫苗和包含来源于线粒体病毒的异源抗原的疫苗
公开(公告)号：EP1622574A2
公开(公告)日：2006-02-08
申请号：EP04809338.9
申请日：2004-04-23
发明人： FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus Dominicus Marcellinus Erasmus , HALLER, Aurelia , TANG, Roderick
IPC分类号： A61K6/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , A61K2039/70 , C12N15/86 , C12N2760/18322 , C12N2760/18334 , C12N2760/18534 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203
摘要： The present invention relates to recombinant bovine parainflueza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulation including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物和/或拯救表达，包装和/或呈递异源的负链RNA重组病毒的重组牛副热病毒（bPIV）cDNA或RNA 基因产物。 特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人类偏肺病毒和禽肺炎病毒。 嵌合病毒和表达产物可有利地用于疫苗制剂，包括针对各种病原体和抗原的疫苗。
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公开(公告)号：EP1351981A2
公开(公告)日：2003-10-15
申请号：EP02710551.9
申请日：2002-01-18
申请人： Vironovative B.V.
发明人： DE JONG, Jan, Cornelius , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, D. M. E. , GROEN, Jan
IPC分类号： C07K14/135
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
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6.发明授权A VIRUS CAUSING RESPIRATORY TRACT ILLNESS IN SUSCEPTIBLE MAMMALS 有权EIN ERKRANKUNGEN DER ATEMWEGE VERURSACHENDES VIRUS INSÄUGERN
公开(公告)号：EP1351981B1
公开(公告)日：2012-08-08
申请号：EP02710551.9
申请日：2002-01-18
申请人： Vironovative B.V.
发明人： DE JONG, Jan, Cornelius , FOUCHIER, Ronaldus, Adrianus, Maria , VAN DEN HOOGEN, Bernadetta, Gerarda , OSTERHAUS, Albertus, D. M. E. , GROEN, Jan
IPC分类号： C07K14/135
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
摘要翻译： 提供了分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。 描述的是分离的哺乳动物负链RNA病毒，其被鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 还描述了哺乳动物MPV，亚组和变体，以及哺乳动物偏肺病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 提供了用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 描述了编码偏肺病毒或其部分的基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 还提供了由所述核苷酸序列编码的嵌合或重组病毒以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。
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公开(公告)号：EP1694830A2
公开(公告)日：2006-08-30
申请号：EP04808721.7
申请日：2004-11-18
申请人： Vironovative B.V.
发明人： DE JONG, Jan, Cornelis , BESTEBROER, Theodorus, Marinus , SIMON, James, Henry, Matthew , FOUCHIER, Ronaldus, Adrianus, Maria , OSTERHAUS, Albertus Dominicus Marcellinus, E.
IPC分类号： C12N7/00
CPC分类号： G01N15/1468 , A61K39/00 , A61K2039/525 , C12N7/00 , C12N2770/20021 , G01N33/56983 , G01N2333/165
摘要： The invention relates to the field of virology. The invention provides a new isolated essentially mammalian positive-sense single stranded RNA virus (EMCR-CoV) within the group of coronaviuses and components thereof.
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