公开(公告)号：EP1404356A2

公开(公告)日：2004-04-07

申请号：EP02746852.9

申请日：2002-06-11

申请人： Medarex, Inc.

发明人： BEBBINGTON, Christopher, R. ,  NIEDER, Matthew, H. ,  CARDARELLI, Pina, M. ,  GANGWAR, Sanjeev ,  PICKFORD, Lesley, B. ,  PAN, Chin

IPC分类号： A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  C07K1/16 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06 ,  C12Q1/37

CPC分类号： G01N33/57492 ,  A61K47/65 ,  C12Q1/37 ,  G01N2333/70596 ,  G01N2500/00

摘要： The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.

公开(公告)号：EP1404356B1

公开(公告)日：2011-04-06

申请号：EP02746852.9

申请日：2002-06-11

申请人： Medarex, Inc.

发明人： BEBBINGTON, Christopher, R. ,  NIEDER, Matthew, H. ,  CARDARELLI, Pina, M. ,  GANGWAR, Sanjeev ,  PICKFORD, Lesley, B. ,  PAN, Chin

IPC分类号： A61K47/48 ,  A61P35/00 ,  C12Q1/37

CPC分类号： G01N33/57492 ,  A61K47/65 ,  C12Q1/37 ,  G01N2333/70596 ,  G01N2500/00

摘要： The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.