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公开(公告)号：EP1940470B1
公开(公告)日：2013-04-17
申请号：EP06825196.6
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： BOYD, Sharon, Elaine , CHEN, Liang , GANWAR, Sanjeev , GUERLAVAIS, Vincent , HORGAN, Kilian , SUFI, Bilal , CARDARELLI, Josephine, M. , PAN, Chin , HUANG, Haichun , KING, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
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公开(公告)号：EP1899379A2
公开(公告)日：2008-03-19
申请号：EP06785284.8
申请日：2006-06-20
申请人： MEDAREX, INC.
发明人： RAO-NAIK, Chetana , KING, David, John , LIU, Jie , HUANG, Haichun , PASSMORE, David, B. , BELL, Alasdair, Fraser , CARDARELLI, Josephine, M. , PAN, Chin , THI DO, To, Uyen , CHEN, Sharline
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：EP1851250B1
公开(公告)日：2012-06-06
申请号：EP06735489.4
申请日：2006-02-17
申请人： Medarex, Inc.
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/21
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
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公开(公告)号：EP2101817A2
公开(公告)日：2009-09-23
申请号：EP07875235.9
申请日：2007-12-13
申请人： Medarex, Inc.
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressιng cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions compnsing the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas ofB lineage, and multiple myelomas using an anti-CD 19 antibody
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公开(公告)号：EP1940470A2
公开(公告)日：2008-07-09
申请号：EP06825196.6
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： BOYD, Sharon, Elaine , CHEN, Liang , GANWAR, Sanjeev , GUERLAVAIS, Vincent , HORGAN, Kilian , SUFI, Bilal , CARDARELLI, Josephine, M. , PAN, Chin , HUANG, Haichun , KING, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
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公开(公告)号：EP1934261A2
公开(公告)日：2008-06-25
申请号：EP06815627.2
申请日：2006-09-26
申请人： MEDAREX, INC.
发明人： TERRETT, Jonathan, Alexander , LU, Li-sheng , KING, David, John , CARDARELLI, Josephine, M. , PAN, Chin , HUANG, Haichun , COCCIA, Marco, A.
IPC分类号： C07K16/28
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
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7.发明公开
公开(公告)号：EP1851250A2
公开(公告)日：2007-11-07
申请号：EP06735489.4
申请日：2006-02-17
申请人： MEDAREX, INC.
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/21
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
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