公开(公告)号：EP2485760A1

公开(公告)日：2012-08-15

申请号：EP10766193.6

申请日：2010-10-08

申请人： Amgen, Inc ,  Medarex, Inc.

发明人： WILD, Kenneth, D. ,  TREANOR, James, J.s. ,  HUANG, Haichun ,  INOUE, Heather ,  ZHANG, Tie, J. ,  MARTIN, Frank

IPC分类号： A61K39/395 ,  C07K16/22 ,  G01N33/53 ,  C12N15/68 ,  C12N5/10 ,  A61P25/00 ,  A61P35/00 ,  A61P19/02 ,  A61P29/02

CPC分类号： C07K16/22 ,  A61K39/00 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

公开(公告)号：EP1915398A2

公开(公告)日：2008-04-30

申请号：EP06787719.1

申请日：2006-07-18

申请人： AMGEN INC. ,  MEDAREX, INC.

发明人： SIU, Gerald ,  SHEN, Wenyan ,  YOSHINAGA, Steven, Kiyoshi ,  HUANG, Haichun

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P11/06 ,  A61K39/395 ,  G01N33/68 ,  G01N33/577 ,  C12N15/13 ,  C12N5/10

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPl antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPl antibodies are also provided.

摘要翻译： 本发明提供了与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。 本发明还提供了所述抗体的药物组合物和中和B7RP1功能的方法，特别是通过施用药学有效量的抗B7RPI抗体来治疗免疫疾病（例如，不适当的免疫应答）。 还提供了使用抗B7RPI抗体检测样品中B7RP1的量的方法。

公开(公告)号：EP1851250B1

公开(公告)日：2012-06-06

申请号：EP06735489.4

申请日：2006-02-17

申请人： Medarex, Inc.

发明人： HUANG, Haichun ,  KING, David, John ,  PAN, Chin ,  CARDARELLI, Josephine, M.

IPC分类号： C07K16/28 ,  A61P13/08

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/21

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.

公开(公告)号：EP1572946B1

公开(公告)日：2012-03-14

申请号：EP03752058.2

申请日：2003-09-05

申请人： Amgen, Inc. ,  Medarex, Inc.

发明人： VARNUM, Brian ,  VEZINA, Chris ,  WITTE, Alison ,  QIAN, Xueming ,  MARTIN, Frank ,  HUANG, Haichun ,  ELLIOTT, Gary

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

公开(公告)号：EP1691837A2

公开(公告)日：2006-08-23

申请号：EP04813771.5

申请日：2004-12-10

申请人： MEDAREX, INC.

发明人： DESHPANDE, Shrikant ,  HUANG, Haichun ,  SRINIVASAN, Mohan ,  CARDARELLI, Josephine, M. ,  WANG, Changyu ,  PASSMORE, David ,  RANGAN, Vangipuram, S. ,  LANE, Thomas, E. ,  KEIRSTEAD, Hans, S. ,  LIU, Michael, T.

IPC分类号： A61K39/395 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

公开(公告)号：EP1940470B1

公开(公告)日：2013-04-17

申请号：EP06825196.6

申请日：2006-09-26

申请人： Medarex, Inc.

发明人： BOYD, Sharon, Elaine ,  CHEN, Liang ,  GANWAR, Sanjeev ,  GUERLAVAIS, Vincent ,  HORGAN, Kilian ,  SUFI, Bilal ,  CARDARELLI, Josephine, M. ,  PAN, Chin ,  HUANG, Haichun ,  KING, David, John

IPC分类号： A61K47/48 ,  C07K16/28 ,  C07K5/06 ,  A61P13/08

CPC分类号： C07K5/06052 ,  A61K38/00 ,  A61K47/6803 ,  A61K47/6805 ,  A61K47/6809 ,  A61K47/6869 ,  A61K47/6889 ,  B82Y30/00

公开(公告)号：EP1648509B1

公开(公告)日：2012-09-12

申请号：EP04778409.5

申请日：2004-07-15

申请人： Amgen Inc. ,  Medarex, Inc.

发明人： WILD, Kenneth, D., Jr. ,  TREANOR, James, J., S. ,  HUANG, Haichun ,  INOUE, Heather ,  ZHANG, Tie, J. ,  MARTIN, Frank

IPC分类号： A61K39/395 ,  C07K16/22 ,  G01N33/53 ,  C12N15/68 ,  C12N5/10 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/74 ,  G01N2333/48 ,  G01N2800/2842

摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

公开(公告)号：EP2102238A2

公开(公告)日：2009-09-23

申请号：EP07863135.5

申请日：2007-12-20

申请人： Medarex, Inc. ,  Pfizer, Inc.

发明人： XU, Xu ,  BEDIAN, Vahe ,  MEADDOUGH, Erika ,  HUANG, Haichun ,  YANG, Lan ,  TOY, Kristopher ,  SRINIVASAN, Mohan ,  BADKAR, Advait V.

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K16/2884 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human CD44 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions or medicaments for treatment.

公开(公告)号：EP1963371A2

公开(公告)日：2008-09-03

申请号：EP06840171.0

申请日：2006-12-08

申请人： Medarex, Inc.

发明人： KORMAN, Alan J. ,  SELBY, Mark J. ,  LU, Li-Sheng ,  WITTE, Alison ,  HUANG, Haichun

IPC分类号： C07K16/28 ,  G01N33/53 ,  A61P35/00

CPC分类号： C07K16/2827 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/55 ,  C12N15/00 ,  C12N15/09 ,  C12N15/62

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

公开(公告)号：EP1907424A2

公开(公告)日：2008-04-09

申请号：EP06786260.7

申请日：2006-06-30

申请人： MEDAREX, INC.

发明人： KORMAN, Alan, J. ,  SELBY, Mark, J. ,  WANG, Changyu ,  SRINIVASAN, Mohan ,  PASSMORE, David, B. ,  HUANG, Haichun ,  CHEN, Haibin

IPC分类号： C07K16/28

CPC分类号： C07K16/2827 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-Ll with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-Ll, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-Ll antibodies.