公开(公告)号：EP1198581A1

公开(公告)日：2002-04-24

申请号：EP00954493.3

申请日：2000-07-13

申请人： MediGene Aktiengesellschaft

发明人： HALLEK, Michael ,  GIROD, Anne ,  RIED, Martin

IPC分类号： C12N15/864 ,  C12N15/35 ,  C12N15/62 ,  C07K14/015 ,  C12N5/10 ,  A61K39/23 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N2750/14122 ,  C12N2750/14143

摘要： The invention relates to a structural protein of adeno-associated virus (AAV) that contains at least one modification that reduces the antigenicity of said virus. The invention further relates to the production of said structural protein and to its use.

公开(公告)号：EP1198580A1

公开(公告)日：2002-04-24

申请号：EP00951400.1

申请日：2000-07-18

申请人： MediGene Aktiengesellschaft

发明人： HALLEK, Michael ,  GIROD, Anne ,  RIED, Martin ,  KÖRNER, Christof ,  MOEBIUS, Ulrich

IPC分类号： C12N15/864 ,  C12N15/35 ,  C12N15/62 ,  C07K14/015 ,  C07K19/00 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/68 ,  A61K39/23 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2810/50

摘要： The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof.

公开(公告)号：EP1088075A2

公开(公告)日：2001-04-04

申请号：EP99929292.3

申请日：1999-06-21

申请人： MediGene Aktiengesellschaft

发明人： HALLEK, Michael ,  RIED, Martin ,  DELEAGE, Gilbert ,  GIROD, Anne

IPC分类号： C12N15/35 ,  C12N15/62 ,  C07K14/015 ,  C12N5/10 ,  A61K39/23 ,  A61K48/00 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C12N2750/14122

摘要： The invention relates to an AAV (Adeno-associated virus) scleroprotein, containing at least one mutation that increases the infectiousness of the virus.