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公开(公告)号：EP2501415B1
公开(公告)日：2015-03-18
申请号：EP10781995.5
申请日：2010-11-19
发明人： KAMALY, Nazila , KALBER, Tammy, Louise , KENNY, Gavin, David , THANOU, Maya , MILLER, Andrew, David , BELL, Jimmy
CPC分类号： A61K49/1812 , B82Y5/00 , Y10S977/773
摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N'-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
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公开(公告)号：EP2501415A1
公开(公告)日：2012-09-26
申请号：EP10781995.5
申请日：2010-11-19
发明人： KAMALY, Nazila , KALBER, Tammy, Louise , KENNY, Gavin, David , THANOU, Maya , MILLER, Andrew, David , BELL, Jimmy
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , B82Y5/00 , Y10S977/773
摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N'-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
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公开(公告)号：EP1976550A2
公开(公告)日：2008-10-08
申请号：EP06831456.6
申请日：2006-12-22
CPC分类号： C07K14/4747
摘要： The present invention relates to the treatment and/or prophylaxis of a disease through the regulation of one or more genes involved in apoptosis. The invention also relates to a vector for use in regulating expression of the one or more genes in the treatment and/or prophylaxis of a disease involving apoptosis.
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