公开(公告)号：EP2501415B1

公开(公告)日：2015-03-18

申请号：EP10781995.5

申请日：2010-11-19

申请人： Medical Research Council ,  Imperial Innovations Limited

发明人： KAMALY, Nazila ,  KALBER, Tammy, Louise ,  KENNY, Gavin, David ,  THANOU, Maya ,  MILLER, Andrew, David ,  BELL, Jimmy

IPC分类号： A61K49/18 ,  B82Y15/00

CPC分类号： A61K49/1812 ,  B82Y5/00 ,  Y10S977/773

摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N'-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.

公开(公告)号：EP2501415A1

公开(公告)日：2012-09-26

申请号：EP10781995.5

申请日：2010-11-19

申请人： Medical Research Council ,  Imperial Innovations Limited

发明人： KAMALY, Nazila ,  KALBER, Tammy, Louise ,  KENNY, Gavin, David ,  THANOU, Maya ,  MILLER, Andrew, David ,  BELL, Jimmy

IPC分类号： A61K49/18

CPC分类号： A61K49/1812 ,  B82Y5/00 ,  Y10S977/773

摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N'-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.