公开(公告)号：EP3450430A1

公开(公告)日：2019-03-06

申请号：EP17788799.9

申请日：2017-04-27

申请人： Medshine Discovery Inc.

发明人： SUN, Fei ,  DING, Charles Z. ,  CAI, Zhe ,  QIAN, Wenyuan ,  HU, Guoping ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D403/14 ,  A61K31/4184 ,  A61P35/00

摘要： The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in fomulas (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4006029A1

公开(公告)日：2022-06-01

申请号：EP20844870.4

申请日：2020-07-23

申请人： Medshine Discovery Inc.

发明人： CAI, Yaxian ,  YAN, Xiaobing ,  CAI, Zhe ,  HU, Guoping ,  DING, Charles Z. ,  CHEN, Kevin X ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D471/18 ,  C07D487/18 ,  A61K31/439 ,  A61P9/10 ,  A61P7/02

摘要： Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof.