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公开(公告)号：EP3988553A1
公开(公告)日：2022-04-27
申请号：EP20827468.8
申请日：2020-06-19
发明人： CHEN, Kevin X , ZHANG, Li , ZHOU, Kai , YU, Yanxin , HU, Boyu , ZHANG, Huiyu
IPC分类号： C07D498/04 , A61K31/517 , A61P35/00 , C07D403/12 , C07D405/14
摘要： The present invention relates to a crystal form and a salt of a compound serving as a Pan-HER tyrosine kinase inhibitor and a preparation method therefor, and also use thereof in the preparation of a medicament for treating solid tumors.
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公开(公告)号：EP3992189A1
公开(公告)日：2022-05-04
申请号：EP20831428.6
申请日：2020-06-24
发明人： CHEN, Kevin X , CHEN, Zhaoguo , ZHANG, Li , HU, Boyu , CHEN, Shuhui
IPC分类号： C07D403/10 , C07D487/00 , A61K31/495 , A61K31/47 , A61P35/00
摘要： Disclosed in the present invention are a compound as represented by formula (I), and an isomer or pharmaceutically acceptable salt thereof, and disclosed is an application thereof in preparing drugs for treating DNA-PK inhibitor-related diseases.
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公开(公告)号：EP4219461A1
公开(公告)日：2023-08-02
申请号：EP21871464.0
申请日：2021-09-18
发明人： CHEN, Kevin X , GUO, Zuhao , YU, Yanxin , HU, Boyu , WANG, Jingjing , CHEN, Zhaoguo , XIE, Cheng , XIONG, Jian , FANG, Yongbo , LIU, Yingtao , LI, Jian , CHEN, Shuhui
IPC分类号： C07D401/12 , C07D413/12 , C07D217/04 , A61K31/4725 , A61P35/00
摘要： A series of tetrahydroisoquinoline derivatives and the crystal forms thereof. Specifically disclosed are a compound as represented by formula (VII), a crystal form thereof, and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3733663A1
公开(公告)日：2020-11-04
申请号：EP18890726.5
申请日：2018-12-19
发明人： CHEN, Kevin X , WEI, XiaWei , ZHANG, Li , YU, Yanxin , ZHOU, Kai , HU, Boyu , CHEN, Zhaoguo , ZHANG, Huiyu , CHEN, Shuhui
IPC分类号： C07D403/12 , C07D405/14 , A61K31/517 , C07D409/14 , C07D413/14 , C07D498/04 , A61P35/00
摘要： The present invention relates to a series of quinazoline compounds, especially compounds as represented by formula (I), isomers thereof or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use thereof as Pan-HER tyrosine kinase inhibitors.
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公开(公告)号：EP3712157A1
公开(公告)日：2020-09-23
申请号：EP18872475.1
申请日：2018-11-02
发明人： CHEN, Kevin X , CHEN, Zhaoguo , ZHANG, Li , YU, Yanxin , ZHOU, Kai , HU, Boyu , WANG, Xiaofei , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D519/00 , C07D471/04 , A61K31/5386 , A61K31/5383 , A61K31/5377 , A61P35/00 , A61P35/02
摘要： Disclosed are a series of pyridopyrimidine compounds and a use of same in the preparation of drugs associated with mTORC 1/2 double-kinase activity inhibitors, and specifically disclosed is a use of the compounds as shown in formula (IV), tautomers thereof or pharmaceutically acceptable salts thereof in the preparation of drugs associated with mTORC 1/2 double-kinase activity inhibitors.
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公开(公告)号：EP3466950A1
公开(公告)日：2019-04-10
申请号：EP17805892.1
申请日：2017-06-02
发明人： HU, Boyu , DING, Charles Z. , HUANG, Zhigang , LIN, Ruibin , XIAO, Minliang , XIE, Jinsheng , CHEN, Shuhui , LI, Cheng
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
摘要： Disclosed in the present invention is a type of novel β-lactamase inhibitors, and specifically disclosed are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4067359A1
公开(公告)日：2022-10-05
申请号：EP20892868.9
申请日：2020-11-25
发明人： CHEN, Kevin X , XIA, Shanghua , CHEN, Zhaoguo , GUO, Zuhao , YU, Yanxin , ZHOU, Kai , HU, Boyu , ZHANG, Li , JIANG, Fen , WANG, Jingjing , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D473/18 , C07D519/00 , A61K31/522 , A61P35/00
摘要： A class of DNA-PK inhibitors, in particular a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug relating to a DNA-PK inhibitor.
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公开(公告)号：EP4063371A1
公开(公告)日：2022-09-28
申请号：EP20889371.9
申请日：2020-11-20
发明人： CHEN, Kevin X , XIA, Shanghua , CHEN, Zhaoguo , GUO, Zuhao , YU, Yanxin , ZHOU, Kai , HU, Boyu , ZHANG, Li , JIANG, Fen , WANG, Jingjing , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D491/20 , A61K31/519 , A61K31/496 , A61P35/00 , A61P35/02
摘要： Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.
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9.发明公开
公开(公告)号：EP3792263A1
公开(公告)日：2021-03-17
申请号：EP19799711.7
申请日：2019-05-08
发明人： CHEN, Kevin X , JIANG, Fen , CHEN, Xinde , ZHANG, Li , CHEN, Zhaoguo , YU, Yanxin , ZHOU, Kai , HU, Boyu , XIE, Cheng , CHEN, Shuhui
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
摘要： The present invention relates to a group of pyrrolo[2, 1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
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