-
公开(公告)号：EP4067359A1
公开(公告)日：2022-10-05
申请号：EP20892868.9
申请日：2020-11-25
发明人： CHEN, Kevin X , XIA, Shanghua , CHEN, Zhaoguo , GUO, Zuhao , YU, Yanxin , ZHOU, Kai , HU, Boyu , ZHANG, Li , JIANG, Fen , WANG, Jingjing , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D473/18 , C07D519/00 , A61K31/522 , A61P35/00
摘要： A class of DNA-PK inhibitors, in particular a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug relating to a DNA-PK inhibitor.
-
公开(公告)号：EP3150600A1
公开(公告)日：2017-04-05
申请号：EP15799888.1
申请日：2015-05-27
发明人： HE, Haiying , ZHOU, Kai , QIN, Hua , LI, Xiaolin , ZHOU, Yuedong , WANG, Xiaofei , CHI, Xuemei , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/04 , A61K31/519 , A61P31/20 , C07D487/04 , C07D498/04 , C07D487/10 , A61K31/527 , A61K31/5377 , A61P1/16
CPC分类号： C07D513/04 , A61K31/519 , A61K31/527 , A61K31/5377 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/04
摘要： Disclosed is a dihydropyrimido loop derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了作为HBV抑制剂的二氢嘧啶环衍生物，特别涉及如式（I）所示的化合物或其药学上可接受的盐。
-
公开(公告)号：EP4129997A1
公开(公告)日：2023-02-08
申请号：EP21781242.9
申请日：2021-04-06
发明人： CHEN, Shuhui , CHEN, Kevin X , ZHOU, Kai , JIANG, Wen , HU, Guoping , LI, Jian
IPC分类号： C07D403/14 , C07D413/14 , C07D498/22 , A61K31/551 , A61K31/553 , A61P35/00
摘要： Disclosed is a class of octahydropyrazinodiazanaphthyridine dione compounds, and specifically disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.
-
4.发明公开
公开(公告)号：EP3967698A1
公开(公告)日：2022-03-16
申请号：EP20802767.2
申请日：2020-05-06
发明人： CHEN, Kevin X , CHEN, Zhaoguo , ZHANG, Li , YU, Yanxin , ZHOU, Kai , JIANG, Fen , XIA, Shanghua , WANG, Xiaofei
IPC分类号： C07D519/00 , C07D471/04 , A61K31/5386 , A61K31/5377 , A61P35/00 , A61P35/02
摘要： Disclosed are a salt and a crystal form of an mTORC1/2 dual kinase inhibitor and a preparation method therefor. Also disclosed is use of the salt and crystal form in the preparation of a medicament related to the mTORC1/2 dual kinase inhibitor. (I)
-
公开(公告)号：EP3733663A1
公开(公告)日：2020-11-04
申请号：EP18890726.5
申请日：2018-12-19
发明人： CHEN, Kevin X , WEI, XiaWei , ZHANG, Li , YU, Yanxin , ZHOU, Kai , HU, Boyu , CHEN, Zhaoguo , ZHANG, Huiyu , CHEN, Shuhui
IPC分类号： C07D403/12 , C07D405/14 , A61K31/517 , C07D409/14 , C07D413/14 , C07D498/04 , A61P35/00
摘要： The present invention relates to a series of quinazoline compounds, especially compounds as represented by formula (I), isomers thereof or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use thereof as Pan-HER tyrosine kinase inhibitors.
-
公开(公告)号：EP3712157A1
公开(公告)日：2020-09-23
申请号：EP18872475.1
申请日：2018-11-02
发明人： CHEN, Kevin X , CHEN, Zhaoguo , ZHANG, Li , YU, Yanxin , ZHOU, Kai , HU, Boyu , WANG, Xiaofei , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D519/00 , C07D471/04 , A61K31/5386 , A61K31/5383 , A61K31/5377 , A61P35/00 , A61P35/02
摘要： Disclosed are a series of pyridopyrimidine compounds and a use of same in the preparation of drugs associated with mTORC 1/2 double-kinase activity inhibitors, and specifically disclosed is a use of the compounds as shown in formula (IV), tautomers thereof or pharmaceutically acceptable salts thereof in the preparation of drugs associated with mTORC 1/2 double-kinase activity inhibitors.
-
公开(公告)号：EP4458812A1
公开(公告)日：2024-11-06
申请号：EP22914793.9
申请日：2022-12-27
发明人： FU, Zhifei , LUO, Miaorong , YU, Chenxi , ZHOU, Kai , GAO, Na , ZHANG, Yang , LI, Jian , CHEN, Shuhui
IPC分类号： C07D237/32 , C07D403/10 , C07D487/00 , A61K31/502 , A61P35/00
摘要： Provided are a pyrazole-1(2H)-phthalazinone compound and an application thereof as a PRMTS. MTA complex inhibitor in the preparation of a drug for treating related diseases.
-
公开(公告)号：EP3988553A1
公开(公告)日：2022-04-27
申请号：EP20827468.8
申请日：2020-06-19
发明人： CHEN, Kevin X , ZHANG, Li , ZHOU, Kai , YU, Yanxin , HU, Boyu , ZHANG, Huiyu
IPC分类号： C07D498/04 , A61K31/517 , A61P35/00 , C07D403/12 , C07D405/14
摘要： The present invention relates to a crystal form and a salt of a compound serving as a Pan-HER tyrosine kinase inhibitor and a preparation method therefor, and also use thereof in the preparation of a medicament for treating solid tumors.
-
公开(公告)号：EP4063371A1
公开(公告)日：2022-09-28
申请号：EP20889371.9
申请日：2020-11-20
发明人： CHEN, Kevin X , XIA, Shanghua , CHEN, Zhaoguo , GUO, Zuhao , YU, Yanxin , ZHOU, Kai , HU, Boyu , ZHANG, Li , JIANG, Fen , WANG, Jingjing , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07D491/20 , A61K31/519 , A61K31/496 , A61P35/00 , A61P35/02
摘要： Provided are a class of DNA-PK inhibitor, and specifically, a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of DNA-PK inhibitor-related drugs.
-
10.发明公开
公开(公告)号：EP3792263A1
公开(公告)日：2021-03-17
申请号：EP19799711.7
申请日：2019-05-08
发明人： CHEN, Kevin X , JIANG, Fen , CHEN, Xinde , ZHANG, Li , CHEN, Zhaoguo , YU, Yanxin , ZHOU, Kai , HU, Boyu , XIE, Cheng , CHEN, Shuhui
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
摘要： The present invention relates to a group of pyrrolo[2, 1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.016 秒)
