公开(公告)号：EP3611174A1

公开(公告)日：2020-02-19

申请号：EP18781739.0

申请日：2018-04-08

申请人： Medshine Discovery Inc.

发明人： CHEN, Kevin X ,  YU, Yanxin ,  CHEN, Xinde ,  ZHANG, Li ,  CHEN, Zhaoguo ,  XIE, Cheng ,  WANG, Xiaofei ,  WU, Linghui ,  HU, Guoping ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61K31/519 ,  A61P25/16 ,  A61P43/00

摘要： Provided are a compound represented by formula (I), an isomer or a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to A 2A receptor. The R 1 , R 2 , R 3 , ring A, ring B, n, and m are as defined in the specification.

公开(公告)号：EP4219461A1

公开(公告)日：2023-08-02

申请号：EP21871464.0

申请日：2021-09-18

申请人： Medshine Discovery Inc.

发明人： CHEN, Kevin X ,  GUO, Zuhao ,  YU, Yanxin ,  HU, Boyu ,  WANG, Jingjing ,  CHEN, Zhaoguo ,  XIE, Cheng ,  XIONG, Jian ,  FANG, Yongbo ,  LIU, Yingtao ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D401/12 ,  C07D413/12 ,  C07D217/04 ,  A61K31/4725 ,  A61P35/00

摘要： A series of tetrahydroisoquinoline derivatives and the crystal forms thereof. Specifically disclosed are a compound as represented by formula (VII), a crystal form thereof, and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3766884A1

公开(公告)日：2021-01-20

申请号：EP19793622.2

申请日：2019-04-28

申请人： Medshine Discovery Inc.

发明人： CHEN, Kevin X ,  YU, Yanxin ,  CHEN, Xinde ,  ZHANG, Li ,  CHEN, Zhaoguo ,  XIE, Cheng

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61K31/519 ,  A61P25/16 ,  A61P35/00

摘要： Disclosed in the present invention are a crystal form of a [1,2,4]triazol[1,5-c]pyrimidine compound and a preparation method therefor. Further disclosed is a use of the crystal form in the preparation of a medicine for treating A 2A receptor related diseases. (I)

公开(公告)号：EP3792263A1

公开(公告)日：2021-03-17

申请号：EP19799711.7

申请日：2019-05-08

申请人： Medshine Discovery Inc.

发明人： CHEN, Kevin X ,  JIANG, Fen ,  CHEN, Xinde ,  ZHANG, Li ,  CHEN, Zhaoguo ,  YU, Yanxin ,  ZHOU, Kai ,  HU, Boyu ,  XIE, Cheng ,  CHEN, Shuhui

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00

摘要： The present invention relates to a group of pyrrolo[2, 1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3333157A1

公开(公告)日：2018-06-13

申请号：EP16834592.4

申请日：2016-08-03

申请人： Harbin Zhenbao Pharmaceutical Co., Ltd. ,  Medshine Discovery Inc.

发明人： CHEN, Shuhui ,  CHEN, Zhengxia ,  DAI, Meibi ,  XIE, Cheng ,  LI, Peng ,  ZHANG, Yang ,  LIANG, Guibai ,  WANG, Qiang ,  LIAO, Jiangpeng ,  SUN, Fei ,  HU, Guoping ,  LI, Jian

IPC分类号： C07D235/02 ,  C07D401/02 ,  C07D401/14 ,  C07D403/02 ,  C07D403/14 ,  A61K31/395 ,  A61K31/416 ,  A61P35/00

CPC分类号： C07D401/14 ,  A61K31/395 ,  A61K31/416 ,  A61P35/00 ,  C07D235/02 ,  C07D401/02 ,  C07D401/12 ,  C07D403/02 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.