公开(公告)号：EP1506027B1

公开(公告)日：2006-09-13

申请号：EP03741809.2

申请日：2003-05-22

申请人： MEDTRONIC, INC.

发明人： MORRIS, Mary, M. ,  FERNANDES, Brian, C., A. ,  SPEAR, Stanton, C. ,  BERGAN, Matthew, A. ,  GARDESKI, Kenneth, C.

IPC分类号： A61L27/38 ,  A61L27/50 ,  A61K49/04

CPC分类号： A61L27/3895 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/50

摘要： A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid.

公开(公告)号：EP1506027A1

公开(公告)日：2005-02-16

申请号：EP03741809.2

申请日：2003-05-22

申请人： Medtronic, Inc.

发明人： MORRIS, Mary, M. ,  FERNANDES, Brian, C., A. ,  SPEAR, Stanton, C. ,  BERGAN, Matthew, A. ,  GARDESKI, Kenneth, C.

IPC分类号： A61L27/38 ,  A61L27/50 ,  A61K49/04

CPC分类号： A61L27/3895 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/50

摘要： A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid.

公开(公告)号：EP1928513A2

公开(公告)日：2008-06-11

申请号：EP06788470.0

申请日：2006-07-26

申请人： MEDTRONIC, INC.

发明人： MORRIS, Mary, M. ,  BERGAN, Matthew, A. ,  FERNADES, Brian, C.A. ,  GARDESKI, Kenneth, C. ,  SPEAR, Stanten, C.

IPC分类号： A61L27/38

CPC分类号： A61L27/50 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/38 ,  A61L27/3895

摘要： A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid

公开(公告)号：EP1931767A1

公开(公告)日：2008-06-18

申请号：EP06774333.6

申请日：2006-06-28

申请人： Medtronic, Inc.

发明人： LYU, Suping ,  FERNANDES, Brian ,  BERGAN, Matthew, A.

IPC分类号： C12N5/06

CPC分类号： A61K9/0019 ,  A61K47/32 ,  C12N5/0658

摘要： Cell delivery compositions including shear thinning polymers and their use in cell delivery are described. The cell delivery compositions include shear thinning polymers that confer higher viscosity when at rest and decreased viscosity when subject to shear stress when dissolved or suspended in a carrier liquid. These shear thinning properties can facilitate cell delivery. Shear thinning polymer solutions may be used to deliver cells to particular tissue sites in a subject.

公开(公告)号：EP0959812B1

公开(公告)日：2005-01-26

申请号：EP97926452.0

申请日：1997-05-12

申请人： Medtronic, Inc.

发明人： BERG, Eric, P. ,  WOLFF, Rodney, G. ,  LINDELL, Elaine, P. ,  TRESCONY, Paul, V. ,  BERGAN, Matthew, A. ,  SCHWARTZ, Robert, S.

IPC分类号： A61F2/06 ,  B29C41/20 ,  B29C41/14

CPC分类号： A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  B29C41/14 ,  B29C41/20 ,  B29K2105/04 ,  B29L2031/7532 ,  Y10S623/921

摘要： Intraluminal stents and methods of manufacturing intraluminal stents are disclosed in which the stents have a plurality of recesses in the body of the stent, at least some of the recesses preferably providing a plurality of passageways between the inner and outer surfaces of the stent. The preferred stents are constructed of films on support structures having spaced apart elements, with the films having a thickness of between about 25 micrometers and about 400 micrometers. The stent can also be treated with an antithrombotic or a thrombolytic substance and, in some cases, the stents can incorporate therapeutic agents for delivery. The methods of manufacturing stents include forming the films using a solid particulate material that can be substantially removed after the film is formed, thereby forming the recesses and corresponding passageways described above. In preferred methods, the solid particulate material is soluble in a solvent in which the film is substantially insolvent.

公开(公告)号：EP0959812A1

公开(公告)日：1999-12-01

申请号：EP97926452.0

申请日：1997-05-12

申请人： MEDTRONIC, INC.

发明人： BERG, Eric, P. ,  WOLFF, Rodney, G. ,  LINDELL, Elaine, P. ,  TRESCONY, Paul, V. ,  BERGAN, Matthew, A. ,  SCHWARTZ, Robert, S.

IPC分类号： A61F2 ,  B29C41

CPC分类号： A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  B29C41/14 ,  B29C41/20 ,  B29K2105/04 ,  B29L2031/7532 ,  Y10S623/921

摘要： Intraluminal stents and methods of manufacturing intraluminal stents are disclosed in which the stents have a plurality of recesses in the body of the stent, at least some of the recesses preferably providing a plurality of passageways between the inner and outer surfaces of the stent. The preferred stents are constructed of films on support structures having spaced apart elements, with the films having a thickness of between about 25 micrometers and about 400 micrometers. The stent can also be treated with an antithrombotic or a thrombolytic substance and, in some cases, the stents can incorporate therapeutic agents for delivery. The methods of manufacturing stents include forming the films using a solid particulate material that can be substantially removed after the film is formed, thereby forming the recesses and corresponding passageways described above. In preferred methods, the solid particulate material is soluble in a solvent in which the film is substantially insolvent.

公开(公告)号：EP0808153B1

公开(公告)日：1999-08-04

申请号：EP96906348.6

申请日：1996-02-08

申请人： MEDTRONIC, INC.

发明人： NELSON, Timothy, S. ,  BERGAN, Matthew, A.

IPC分类号： A61K9/00

CPC分类号： A61K9/0085

摘要： A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.

公开(公告)号：EP0808153A1

公开(公告)日：1997-11-26

申请号：EP96906348.0

申请日：1996-02-08

申请人： MEDTRONIC, INC. ,  Nelson, Timothy S. ,  Bergan, Matthew A.

发明人： NELSON, Timothy, S. ,  BERGAN, Matthew, A.

IPC分类号： A61K9

CPC分类号： A61K9/0085

摘要： A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.