利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.014 秒)

    METHOD FOR COATING MEDICAL DEVICE SURFACES
    1.
    发明授权
    METHOD FOR COATING MEDICAL DEVICE SURFACES 有权
    方法BESCHICHTIGUNG医疗器械

    公开(公告)号：EP1357952B1

    公开(公告)日：2010-09-01

    申请号：EP02720846.1

    申请日：2002-01-23

    申请人： Medtronic, Inc.

    发明人： KEOUGH, James, R. ,  TRESCONY, Paul, V. ,  VERHOEVEN, Michel ,  KOULIK, Edouard

    IPC分类号： A61L27/34

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  C08L83/04

    摘要： A method for coating a medical device with a hydrophilic polymer is provided. One method of the present invention includes chemically binding under appropriate reaction conditions a hydrophilic polymer to a biomaterial surface. Another method of the present invention includes chemically binding under appropriate reaction conditions a hydrophilic polymer to a primer located on a biomaterial surface. Another method of the present invention includes chemically binding under appropriate reaction conditions a biomolecule to a hydrophilic polymer located on a biomaterial surface.

    VASCULAR ELECTRODE SYSTEM FOR ELECTRICAL STIMULATION FOR THROMBOLYTIC THERAPY
    2.
    发明授权
    VASCULAR ELECTRODE SYSTEM FOR ELECTRICAL STIMULATION FOR THROMBOLYTIC THERAPY 有权
    VESSEL电极系统欲了解溶栓治疗电刺激

    公开(公告)号：EP1496988B1

    公开(公告)日：2009-07-01

    申请号：EP03721694.2

    申请日：2003-04-16

    申请人： MEDTRONIC, INC.

    发明人： SOYKAN, Orhan ,  DENO, Curtis, D. ,  TRESCONY, Paul, V. ,  DONOVAN, Maura, G. ,  WILLIAMS, Terrell, M. ,  ROBINSON, Timothy, H.

    IPC分类号： A61N1/32

    CPC分类号： A61N1/326

    摘要： This invention is an electrical stimulation apparatus for delivering an electrical field or electrical current over a predetermined period of time to a vascular tissue (150) in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power support , a control mechanism interconnected with the power supply , and a plurality of electrodes designed to generate an electrical field or electrical current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to, or within the vascular tissue, and the duration of the period of delivery are sufficient to stimulate production of thrombolytic peptides in the vascular tissue. The control mechanism preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulation apparatus to deliver a predetermined amount of electricalcurrent or voltage over a predetermined period of delivery to the plurality of electrodes such that the plurality of electrodes are in contact or proximity with the vascular tissue.

    SEEDING IMPLANTABLE MEDICAL DEVICES WITH CELLS
    4.
    发明公开
    SEEDING IMPLANTABLE MEDICAL DEVICES WITH CELLS 审中-公开
    与细胞植入播种医疗设备

    公开(公告)号：EP1871437A2

    公开(公告)日：2008-01-02

    申请号：EP06736746.6

    申请日：2006-03-02

    申请人： MEDTRONIC, INC.

    发明人： WOLF, Michael, F. ,  YUNKER, Laurie,A. ,  TRESCONY, Paul, V.

    IPC分类号： A61L27/38 ,  A61L27/50 ,  A61L27/16 ,  A61F2/06

    CPC分类号： A61L27/3808 ,  A61F2/062 ,  A61L27/16 ,  A61L27/507 ,  Y10S623/915 ,  Y10S623/916 ,  C08L27/18

    摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

    ELECTRICAL STIMULATION FOR THROMBOLYTIC THERAPY
    6.
    发明公开
    ELECTRICAL STIMULATION FOR THROMBOLYTIC THERAPY 有权
    VESSEL电极系统欲了解溶栓治疗电刺激

    公开(公告)号：EP1496988A2

    公开(公告)日：2005-01-19

    申请号：EP03721694.2

    申请日：2003-04-16

    申请人： Medtronic, Inc.

    发明人： SOYKAN, Orhan ,  DENO, Curtis, D. ,  TRESCONY, Paul, V. ,  DONOVAN, Maura, G. ,  WILLIAMS, Terrell, M. ,  ROBINSON, Timothy, H.

    IPC分类号： A61N1/32

    CPC分类号： A61N1/326

    摘要： An electrical stimulation apparatus is provided for delivering an electrical field or electrical current over a predetermined period of time to a vascular tissue in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power supply, a control mechanism interconnected with the power supply, and a plurality of electrodes designed to generate an electrical field or electrical current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to, or within the vascular tissue, and the duration of the period of delivery are sufficient to stimulate production of thrombolytic peptides in the vascular tissue. The control mechanism preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulation apparatus to deliver a predetermined amount of electricalcurrent or voltage over a predetermined period of delivery to the plurality of electrodes such that the plurality of electrodes are in contact or proximity with the vascular tissue.

    INTRALUMINAL STENT
    7.
    发明公开
    INTRALUMINAL STENT 失效
    该腔内支架

    公开(公告)号：EP0959812A1

    公开(公告)日：1999-12-01

    申请号：EP97926452.0

    申请日：1997-05-12

    申请人： MEDTRONIC, INC.

    发明人： BERG, Eric, P. ,  WOLFF, Rodney, G. ,  LINDELL, Elaine, P. ,  TRESCONY, Paul, V. ,  BERGAN, Matthew, A. ,  SCHWARTZ, Robert, S.

    IPC分类号： A61F2 ,  B29C41

    CPC分类号： A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2240/001 ,  B29C41/14 ,  B29C41/20 ,  B29K2105/04 ,  B29L2031/7532 ,  Y10S623/921

    摘要： Intraluminal stents and methods of manufacturing intraluminal stents are disclosed in which the stents have a plurality of recesses in the body of the stent, at least some of the recesses preferably providing a plurality of passageways between the inner and outer surfaces of the stent. The preferred stents are constructed of films on support structures having spaced apart elements, with the films having a thickness of between about 25 micrometers and about 400 micrometers. The stent can also be treated with an antithrombotic or a thrombolytic substance and, in some cases, the stents can incorporate therapeutic agents for delivery. The methods of manufacturing stents include forming the films using a solid particulate material that can be substantially removed after the film is formed, thereby forming the recesses and corresponding passageways described above. In preferred methods, the solid particulate material is soluble in a solvent in which the film is substantially insolvent.

    IMPLANTABLE MEDICAL DEVICES HAVING RECESSES
    9.
    发明公开
    IMPLANTABLE MEDICAL DEVICES HAVING RECESSES 审中-公开
    植入型凹槽医疗器械

    公开(公告)号：EP1592364A2

    公开(公告)日：2005-11-09

    申请号：EP04783239.9

    申请日：2004-09-02

    申请人： MEDTRONIC, INC.

    发明人： RIVRON, Nicolas, C. ,  TRESCONY, Paul, V. ,  WOLF, Michael, F.

    IPC分类号： A61F2/06

    摘要： In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts modes from the surface, forming recesses that can receive endothelial cells.