公开(公告)号：EP1322748B1

公开(公告)日：2009-12-02

申请号：EP01972471.5

申请日：2001-09-19

申请人： Meiji Dairies Corporation

发明人： LUU, Bang, Chimie Subst. Nat., ULP-CNRS UMR 7123 ,  MOHIER, Eliane, Chimie S. Nat., ULP-CNRS UMR 7123 ,  YAMADA, Masashi, c/o Meiji Dairies Corp. ,  SUMA, Yukie, c/o Meiji Dairies Corp. ,  SUZUKI, Hiroto, c/o Meiji Dairies Corp.

IPC分类号： C12N5/08 ,  A61K31/122 ,  A61K35/12 ,  A61P25/00 ,  C07C50/28

CPC分类号： C07C49/713 ,  C07C45/511 ,  C07C45/59 ,  C07C45/673 ,  C07C403/08 ,  C07C2601/16 ,  C07C49/603

摘要： Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R?1, R2 and R3¿ each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group]. Since the cyclohexenone long-chain alcoholic derivative according to the present invention promotes differentiation-induction of stem cells into cells expressing a specific biological function, a medicament comprising the derivative is useful as a preventive or remedial drug for diseases such as nervous diseases, bone diseases, circulatory diseases and myopathy, caused by the degeneration of tissues or cells or cell death.

摘要翻译： 提供了一种干细胞分化和诱导启动子，其包含由式（1）表示的环己烯酮长链醇衍生物作为有效成分：[其中，R 1，R 2和R 3各自 独立地表示氢原子或甲基，X表示直链或支链的C10-28亚烷基或亚烯基]。 由于根据本发明的环己烯酮长链醇衍生物促进干细胞向表达特定生物学功能的细胞的分化诱导，所以包含该衍生物的药物可用作疾病如神经疾病，骨疾病的预防或补救药物 ，循环系统疾病和肌病，由组织或细胞变性或细胞死亡引起。