公开(公告)号：EP1690848B1

公开(公告)日：2015-05-20

申请号：EP06250243.0

申请日：2006-01-18

Applicant: International Flavors & Fragrances, Inc.

Inventor： Narula, Anubhav P.S. ,  Arruda, Edward Mark ,  Gaurin, Pascal

IPC: C07C33/12 ,  C07C33/14 ,  C07C49/203 ,  C07C49/217

CPC classification number: A61Q13/00 ,  A61K8/34 ,  A61K8/35 ,  C07C33/03 ,  C07C33/12 ,  C07C33/14 ,  C07C45/29 ,  C07C49/203 ,  C07C49/217 ,  C07C49/647 ,  C07C49/794 ,  C07C403/08 ,  C07C2601/08 ,  C07C2601/14

公开(公告)号：EP2723713A1

公开(公告)日：2014-04-30

申请号：EP12728478.4

申请日：2012-06-14

Applicant: DSM IP Assets B.V.

Inventor： BONRATH, Werner ,  NETSCHER, Thomas ,  SCHÜTZ, Jan ,  WÜSTENBERG, Bettina

IPC: C07C403/12 ,  C07C403/16 ,  B01J27/185

CPC classification number: C07C403/12 ,  C07C403/08 ,  C07C403/16 ,  C07C403/24 ,  C07C2601/16 ,  C07F15/006

Abstract: The present invention relates to compounds of formula (I) wherein R1 signifies a C1-C15 alkyl moiety or a C2 to C18 alkenyl moiety, to their process of production as well as to their use in organic synthesis, especially as intermediates (building blocks) in the synthesis of vitamin A or &bgr;-carotene or derivatives thereof, or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin, preferably vitamin A.

Abstract translation: 本发明涉及其中R1表示C1-C15烷基部分或C2至C18烯基部分的式（I）化合物，其生产方法以及它们在有机合成中的用途，特别是作为中间体（构建单元） 在合成维生素A或其中的β-胡萝卜素或其衍生物或其他类胡萝卜素时， 角黄素，虾青素或玉米黄质，优选维生素A.

公开(公告)号：EP1986636B1

公开(公告)日：2013-04-24

申请号：EP07751472.7

申请日：2007-02-22

Applicant: Edison Pharmaceuticals, Inc.

Inventor： MILLER, Guy, M. ,  HECHT, Sidney, M. ,  JANKOWSKI, Orion, D. ,  WESSON, Kieron, E. ,  MOLLARD, Paul

IPC: A61K31/355 ,  A61P3/00 ,  A61P25/28 ,  C07C50/06 ,  C07C215/46 ,  C07C39/19

CPC classification number: C07C50/04 ,  A61K31/05 ,  A61K31/355 ,  C07C39/08 ,  C07C39/11 ,  C07C39/19 ,  C07C39/245 ,  C07C43/225 ,  C07C43/23 ,  C07C47/277 ,  C07C50/02 ,  C07C50/06 ,  C07C50/24 ,  C07C50/28 ,  C07C69/608 ,  C07C69/618 ,  C07C215/56 ,  C07C233/27 ,  C07C233/32 ,  C07C255/37 ,  C07C403/04 ,  C07C403/08 ,  C07C403/18 ,  C07C2601/16

Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.

公开(公告)号：EP2268779B1

公开(公告)日：2013-01-02

申请号：EP09731673.1

申请日：2009-04-14

Applicant: Firmenich S.A.

Inventor： CHAPUIS, Christian ,  BIRKBECK, Anthony ,  MARTY, Maurus

IPC: C11B9/00 ,  C07C49/20 ,  C07C45/00 ,  C07C49/21 ,  C11D3/50 ,  C07C403/08 ,  C07C403/16

CPC classification number: A61Q15/00 ,  A61K8/375 ,  C07C45/004 ,  C07C49/21 ,  C07C403/08 ,  C07C403/16 ,  C07C2601/14 ,  C07C2601/16 ,  C11B9/003 ,  C11B9/0034 ,  C11D3/50

公开(公告)号：EP1947189B1

公开(公告)日：2010-12-01

申请号：EP08003596.7

申请日：1999-07-06

Applicant: DCV Inc. doing business as Bio-Technical Resourses

Inventor： Millis, James R. ,  Saucy, Gabriel G. ,  Maurina-Brunker, Julie ,  McMullin, Thomas W.

IPC: C12P1/02 ,  C07C45/41 ,  C07D303/04 ,  C07D311/72

CPC classification number: C12P7/04 ,  C07C403/08 ,  C07C403/24 ,  C07C2601/16 ,  C07D311/72 ,  C12N9/0004 ,  C12N9/1085 ,  C12P9/00 ,  C12P17/06 ,  C12P23/00 ,  H01Q1/00

公开(公告)号：EP1986636A2

公开(公告)日：2008-11-05

申请号：EP07751472.7

申请日：2007-02-22

Applicant: Edison Pharmaceuticals, Inc.

Inventor： MILLER, Guy, M. ,  HECHT, Sidney, M. ,  JANKOWSKI, Orion, D. ,  WESSON, Kieron, E. ,  MOLLARD, Paul

IPC: A61K31/355 ,  A61P3/00 ,  A61P25/28

CPC classification number: C07C50/04 ,  A61K31/05 ,  A61K31/355 ,  C07C39/08 ,  C07C39/11 ,  C07C39/19 ,  C07C39/245 ,  C07C43/225 ,  C07C43/23 ,  C07C47/277 ,  C07C50/02 ,  C07C50/06 ,  C07C50/24 ,  C07C50/28 ,  C07C69/608 ,  C07C69/618 ,  C07C215/56 ,  C07C233/27 ,  C07C233/32 ,  C07C255/37 ,  C07C403/04 ,  C07C403/08 ,  C07C403/18 ,  C07C2601/16

Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.

Abstract translation: 治疗或抑制线粒体疾病，：如弗里德赖希共济失调（FRDA），肝脏遗传性视神经病（LHON），线粒体脑肌病伴高乳酸血症，中风（MELAS），或卡恩斯 - 塞尔综合征（KSS）的方法是圆盘游离缺失，以及 在发明的方法中有用的化合物。 的方法和化合物治疗的其它病症有用的是这样游离缺失盘。 因此在assesing受试者的代谢状态和治疗的功效有用能量生物标记是游离缺失盘。 调制，正火，或者提高能源的生物标志物的方法，以及用于搜索方法中有用的化合物，所以被游离缺失光盘。

公开(公告)号：EP1794119A1

公开(公告)日：2007-06-13

申请号：EP05785744.3

申请日：2005-09-08

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： GRIMMER, Johannes ,  MÜLLER, Thomas

IPC: C07C403/08 ,  C07D317/64

CPC classification number: C07C403/24 ,  C07C403/08 ,  C07C2601/16

Abstract: The invention relates to a method for producing cyclohexene derivatives of general formulae (I) or (II), by reducing alkine compounds of general formulae (III) or (IV), with a mixture of zinc and at least one ammonium salt of formula (V) as a reducing agent. In said formulae, the substituents R1 to R8 independently have the designation cited in the description. Said method is characterised in that the reducing agent contains between 0.3 and 0.49 mol of at least one ammonium salt of formula (V) per zinc mol.

Abstract translation: 本发明涉及通过用锌和至少一种式V的铵盐作为还原剂的混合物还原通式III或IV的炔化合物来制备通式I或II的环己烯衍生物的方法，其中 取代基R 1至R 8彼此独立地具有本说明书中规定的含义，其中还原剂包含0.3至0.49mol的至少一种铵盐 式V每摩尔锌。

公开(公告)号：EP1053988A4

公开(公告)日：2007-05-02

申请号：EP99901929

申请日：1999-02-01

Applicant: TAKASAGO PERFUMERY CO LTD

Inventor： AIDA TAKASHI ,  MATSUDA HIROYUKI ,  ISHIDA KENYA ,  YAMASAKI TETSURO ,  TAMAI EIKO ,  TOKORO KAZUHIKO

IPC: A61K8/34 ,  A61K8/35 ,  A61Q13/00 ,  A61Q19/02 ,  C07C31/135 ,  C07C33/14 ,  C07C49/11 ,  C07C49/15 ,  C07C403/08 ,  C11B9/00 ,  A61K7/00 ,  C07C49/21

CPC classification number: C11B9/0034 ,  A61K8/34 ,  A61K8/35 ,  A61Q13/00 ,  A61Q19/02 ,  C07C31/1355 ,  C07C33/14 ,  C07C49/11 ,  C07C49/15 ,  C07C403/08 ,  C07C403/16 ,  C07C2601/14

Abstract: Trimethylcyclohexane derivatives represented by general formula (1): wherein A represents C=O or CH-OH; n is 2; R represents hydrogen or methyl; R represents linear or branched and optionally saturated C3-10 hydrocarbyl; and the dotted line represents an optionally saturated carbon-carbon bond; melanin-formation inhibitors and perfume-holding agents containing one or more of the above derivatives, and skin preparations for external use characterized by containing one or more melanin-formation inhibitors and/or perfume-holding agents described above.

公开(公告)号：EP1174405B1

公开(公告)日：2006-01-25

申请号：EP01115391.3

申请日：2001-06-25

Applicant: Merck Patent GmbH

Inventor： Reiffenrath, Volker ,  Lüssem, Georg, Dr.

IPC: C07C13/28 ,  C09K19/30 ,  C07C22/00 ,  C07D319/06 ,  C09K19/34

CPC classification number: C09K19/3003 ,  C07C13/28 ,  C07C22/00 ,  C07C45/44 ,  C07C403/02 ,  C07C403/04 ,  C07C403/08 ,  C07C2601/14 ,  C07D319/06 ,  C09K2019/0496 ,  Y10T428/10 ,  C07C47/34

公开(公告)号：EP1285912B1

公开(公告)日：2005-12-28

申请号：EP02016708.6

申请日：2002-07-26

Applicant: BASF Aktiengesellschaft

Inventor： Grimmer, Johannes ,  Müller, Thomas, Dr. ,  Bomm, Volker, Dr.

IPC: C07C403/08 ,  C07D317/64

CPC classification number: C07C403/08 ,  C07C2601/16 ,  C07D317/64 ,  Y02P20/55