AVERMECTIN DERIVATIVES
    9.
    发明授权
    AVERMECTIN DERIVATIVES 有权
    AVERMECTIN DERIVATE

    公开(公告)号:EP1160252B1

    公开(公告)日:2012-05-02

    申请号:EP00902857.2

    申请日:2000-02-09

    CPC分类号: C07H17/08 A61K31/7048

    摘要: Avermectin derivatives represented by general formula (I) or salts thereof: wherein -X---Y- is -CH=CH-, -CH2-C(=O)-, -CH2-CH2-, or -CH2-CH(R13)-, for example, (1) when -X---Y- is -CH=CH-, R?1 is (R11) (R12¿)C [wherein R11 is optionally substituted lower alkyl, formyl, lower alkoxycarbonyl, or the like, and R12 is hydrogen or lower alkyl], and R2 is hydroxyl, tri (lower alkyl) silyloxy, or the like and linked by a single bond to the 5-position carbon atom, or R2 and the 5-position carbon atom may be united to form a carbonyl or hydroxime group, and (2) when -X---Y- is -CH¿2?-C(=O)-, R?1 is (R11a) (R12a¿)C [wherein R11a is lower alkoxycarbonyl or -COOCH¿2?CH=CH2, and R?12a¿ is hydrogen], and R2 is hydroxyl or tri (lower alkyl) silyloxy.