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公开(公告)号：EP1692278A1
公开(公告)日：2006-08-23
申请号：EP04789595.8
申请日：2004-10-20
申请人： Melbourne Health , Austin Health , Southern Health , Bayside Health , St. Vincent's Hospital (Melbourne) Ltd. trading as St. Vincent's Hospital Melbourne
发明人： BARTHOLOMEUSZ, Angeline, Ingrid , LOCARNINI, Stephen, Alister , AYRES, Anna , YUEN, Lilly, Ka Wai , SASADEUSZ, Joseph, John
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
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公开(公告)号：EP2029747A1
公开(公告)日：2009-03-04
申请号：EP07719028.8
申请日：2007-06-04
申请人： Melbourne Health , Austin Health , Bayside Health , Southern Health , St. Vincent's Hospital (Melbourne) Ltd. trading as St. Vincent's Hospital Melbourne
发明人： BARTHOLOMEUSZ, Angeline, Ingrid , LOCARNINI, Stephen , AYRES, Anna , YUEN, Lilly, Ka Wai , ANGUS, Peter, William , SASADEUSZ, Joseph, John , DESMOND, Paul , TILLMAN, Hans , BOCK, Thomas , SIEVERT, William , LEWIN, Sharon
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
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公开(公告)号：EP1692278B1
公开(公告)日：2013-07-03
申请号：EP04789595.8
申请日：2004-10-20
申请人： Melbourne Health , Austin Health , Southern Health , Alfred Health , St. Vincent's Hospital (Melbourne) Ltd. trading as St. Vincent's Hospital Melbourne
发明人： BARTHOLOMEUSZ, Angeline, Ingrid , LOCARNINI, Stephen, Alister , AYRES, Anna , YUEN, Lilly, Ka Wai , SASADEUSZ, Joseph, John , Angus, Peter William , Sievert, William , Lewin, Sharon Ruth , Desmond, Paul Vincent , Bell. Sally Jane
IPC分类号： C12N7/00 , C12Q1/70 , C07K14/005
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2730/10122 , C12Q1/706
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