利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.028 秒)

    BIOLOGICAL COMPOSITIONS, COMPONENTS THEREOF AND USES THEREFOR
    6.
    发明公开
    BIOLOGICAL COMPOSITIONS, COMPONENTS THEREOF AND USES THEREFOR 审中-公开
    生物成分，COMPONENT体和其用途

    公开(公告)号：EP1135476A1

    公开(公告)日：2001-09-26

    申请号：EP99957236.5

    申请日：1999-11-10

    申请人： Melbourne Health

    发明人： LOCARNINI, Stephen, Alister ,  TORRESI, Joseph ,  EARNEST-SILVEIRA, Linda ,  BARTHOLOMEUSZ, Angeline, Ingrid

    IPC分类号： C12N15/00 ,  A61K39/12

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10161

    摘要： The present invention relates generally to an isolated Hepatitis B virus (HBV) with a surface component exhibiting an altered immunological profile relative to a reference HBV. A reference HBV is considered herein to comprise a composite or consensus nucleotide or amino acid sequence from HBV genotypes A through F. The isolated HBV of the present invention is considered herein to be an HBV variant relative to the reference HBV. The altered immunological profile renders the HBV variants of the present invention less susceptible to vaccines directed to the surface component. The HBV variants of the present invention generally arise from selective pressure following one or both of anti-HBV chemical therapy and in particular chemical therapy aimed at disrupting HBV polymerase activity or function and/or following immune pressure directed to the surface component. Immune pressure may result from natural exposure to HBV or following vaccination with an avirulent or attenuated HBV or with a component of an HBV. The present invention further provides a recombinant polypeptide and derivatives and chemical equivalents thereof corresponding to the surface component of the HBV variants. The HBV variants and recombinant polypeptides and their derivatives and chemical equivalents of the present invention are useful in biological compositions capable of inducing a neutralizing immune response to the HBV variant.

    AN ASSAY FOR DETECTING VARIANT HAPATITIS B VIRUSES (HBVs) WHICH EXHIBIT ALTERED SENSITIVITY TO AGENTS
    10.
    发明公开
    AN ASSAY FOR DETECTING VARIANT HAPATITIS B VIRUSES (HBVs) WHICH EXHIBIT ALTERED SENSITIVITY TO AGENTS 审中-公开
    分析法的乙型肝炎病毒变异（HBVS）的检测是什么改变SENSITIVITY TO AGENTS HAVING

    公开(公告)号：EP1257661A1

    公开(公告)日：2002-11-20

    申请号：EP01903503.9

    申请日：2001-02-02

    申请人： Melbourne Health ,  THE PENN STATE RESEARCH FOUNDATION

    发明人： DELANEY, William, IV ,  LOCARNINI, Stephen, Alister ,  CHEN, Robert, Yung, Ming ,  BARTHOLOMEUSZ, Angeline ,  ISOM, HarrietDep. of Microbiology and Immunology

    IPC分类号： C12Q1/48 ,  C12Q1/70

    CPC分类号： G01N33/5761 ,  G01N2800/52

    摘要： The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a baculovirus vector. The same agents generally have a particular effect or absence of effect on a reference HBV. The altered sensitivity is in relation to the effects of the agent on one or more stages of infection, replication, assembly or release of virus or virus-like particles including any intermediary steps during the processes of viral infection, replication, assembly and/or release. The identification of variant HBVs with altered sensitivities to anti-HBV agents provides a means of monitoring cross resistance, or the development of new therapeutics effective against variant HBVs with altered sensitivities to other anti-HBV agents, as well as monitoring therapeutic protocols which may then need to be modified to ensure the appropriate anti-HBV agent is administered or that the appropriate therapeutic protocol is instituted. The present invention further provides variant HBVs detected by the assay of the present invention and to components thereof as well as recombinant, chemical analogue, homologue and derivative forms of such components.