公开(公告)号：EP1986652A2

公开(公告)日：2008-11-05

申请号：EP07750399.3

申请日：2007-02-09

申请人： Merck & Co., Inc.

发明人： BIFTU, Tesfaye ,  CALDWELL, Charles, G. ,  WEBER, Ann, E. ,  CHEN, Ping ,  QIAN, Xiaoxia ,  FENG, Danqing ,  COX, Jason, M.

IPC分类号： A61K31/519

CPC分类号： C07D471/04 ,  C07D405/04 ,  C07D487/04

摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

公开(公告)号：EP1962601A2

公开(公告)日：2008-09-03

申请号：EP06845127.7

申请日：2006-12-08

申请人： Merck & Co., Inc.

发明人： COX, Jason, M. ,  EDMONDSON, Scott, D. ,  MASTRACCHIO, Anthony

IPC分类号： A01N43/40 ,  A61K31/45

CPC分类号： C07D471/14

摘要： The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.

公开(公告)号：EP1921917A2

公开(公告)日：2008-05-21

申请号：EP06813692.8

申请日：2006-08-22

申请人： Merck & Co., Inc.

发明人： COX, Jason, M. ,  EDMONDSON, Scott, D. ,  MASTRACCHIO, Anthony

IPC分类号： A01N43/58 ,  A61K31/497 ,  C07D471/04

CPC分类号： C07D471/14

摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DPP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

公开(公告)号：EP1819674A2

公开(公告)日：2007-08-22

申请号：EP05849849.4

申请日：2005-11-22

申请人： Merck & Co., Inc.

发明人： EDMONDSON, Scott, D. ,  MASTRACCHIO, Anthony ,  COX, Jason, M.

IPC分类号： C07D211/06

CPC分类号： C07D471/14 ,  C07D471/04

摘要： The present invention is directed to novel substituted fused aminopipeiridines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

公开(公告)号：EP1796669A2

公开(公告)日：2007-06-20

申请号：EP05802868.9

申请日：2005-09-27

申请人： Merck & Co., Inc.

发明人： COX, Jason, M. ,  EDMONDSON, Scott, D. ,  HARPER, Bart ,  WEBER, Ann, E.

IPC分类号： A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/525 ,  C07D237/26 ,  C07D239/00 ,  C07D239/70 ,  C07D239/72 ,  C07D241/00 ,  C07D241/36 ,  C07D401/04 ,  C07D471/04 ,  C07D491/04 ,  C07D487/00

CPC分类号： C07D401/04 ,  C07D471/04 ,  C07D487/04

摘要： The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DPP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.