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    Recombinant human HIV-neutralizing monoclonal antibodies for prevention and treatment of HIV infection
    1.
    发明公开
    Recombinant human HIV-neutralizing monoclonal antibodies for prevention and treatment of HIV infection 失效
    HIV中和HIV感染的治疗和预防的重组抗体。

    公开(公告)号：EP0577243A2

    公开(公告)日：1994-01-05

    申请号：EP93302546.2

    申请日：1993-03-31

    申请人： MERCK & CO. INC.

    发明人： Emini, Emilio A. ,  Conley, Anthony J. ,  Mark, George E. ,  Johnson, L. Syd ,  Pfarr, David S.

    IPC分类号： C12N15/13 ,  C12P21/08 ,  C12N5/10 ,  A61K39/395

    CPC分类号： C07K16/1063 ,  A61K38/00

    摘要： Recombinant human immunoglobulin molecules neutralizing for HIV-1, methods of production of the immunoglobulins and methods of preventing HIV-1 infection using the immunoglobulins are disclosed. DNA constructs containing the complementarity determining regions (CDRs) and framework (FRs) of the native human antibody are combined with other constant regions, and expressed in recombinant host cells. These recombinant antibodies are useful for the treatment and prevention of HIV-1 infection in vivo .

    摘要翻译： 重组人免疫球蛋白分子中和HIV-1，生产的免疫球蛋白和预防使用的免疫球蛋白的HIV-1感染的方法的方法是游离缺失光盘。 含天然人抗体的互补决定区（CDR）和框架（FR）的DNA构建体相结合，与其它恒定区，并在重组宿主细胞中过表达。 这些重组抗体可用于HIV-1感染的体内治疗和预防是有用的。

    Synergism of HIV reverse transcriptase inhibitors
    2.
    发明公开
    Synergism of HIV reverse transcriptase inhibitors 失效
    HIV逆转录酶抑制剂的协同作用

    公开(公告)号：EP0484071A3

    公开(公告)日：1992-11-25

    申请号：EP91309915.6

    申请日：1991-10-28

    申请人： MERCK & CO. INC.

    发明人： Friedman, Paul A. ,  Emini, Emilio A. ,  Nunberg, Jack ,  Quintero, Julio C.

    IPC分类号： A61K31/44 ,  A61K31/70 ,  A61K31/505

    CPC分类号： A61K31/70 ,  A61K31/44 ,  A61K2300/00

    摘要： The combination of certain aminopyridones and anti-HIV nucleoside analogs has been found to synergistically inhibit HIV reverse transcriptase. This combination is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a combination of compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in further combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

    Synergism of HIV reverse transcriptase inhibitors
    3.
    发明公开
    Synergism of HIV reverse transcriptase inhibitors 失效
    协同增效HIV逆转录酶。

    公开(公告)号：EP0484071A2

    公开(公告)日：1992-05-06

    申请号：EP91309915.6

    申请日：1991-10-28

    申请人： MERCK & CO. INC.

    发明人： Friedman, Paul A. ,  Emini, Emilio A. ,  Nunberg, Jack ,  Quintero, Julio C.

    IPC分类号： A61K31/44 ,  A61K31/70 ,  A61K31/505

    CPC分类号： A61K31/70 ,  A61K31/44 ,  A61K2300/00

    摘要： The combination of certain aminopyridones and anti-HIV nucleoside analogs has been found to synergistically inhibit HIV reverse transcriptase. This combination is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a combination of compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in further combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 已经发现某些氨基吡啶酮和抗HIV核苷类似物的组合协同地抑制HIV逆转录酶。 这种组合可用于预防或治疗艾滋病毒感染和艾滋病的治疗，作为化合物，药学上可接受的盐，药物组合物成分的组合，无论是否与其他抗病毒药物，抗感染剂，免疫调节剂， 抗生素或疫苗。 还描述了治疗AIDS的方法和预防或治疗HIV感染的方法。

    Coconjugate vaccines comprising immunogenic protein, HIV related peptides, and anionic moieties
    4.
    发明公开
    Coconjugate vaccines comprising immunogenic protein, HIV related peptides, and anionic moieties 失效
    Impfstoffkonjugatkomplex，das ein immunogenes Protein，HIV-relatierte Peptide und anionischen Gruppenenthält。

    公开(公告)号：EP0467700A2

    公开(公告)日：1992-01-22

    申请号：EP91306598.3

    申请日：1991-07-19

    申请人： MERCK & CO. INC.

    发明人： Leanza, William J. ,  Marburg, Stephen ,  Tolman, Richard L. ,  Emini, Emilio A.

    IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K7/10 ,  C07K7/52 ,  C07K7/54 ,  C07K15/04 ,  A61K47/48 ,  A61K39/21 ,  A61K37/02

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/22 ,  C07K16/1063 ,  C07K16/1217 ,  C12N2740/16122

    摘要： A novel coconjugate comprising an immunogenic protein or protein complex having a first set of covalent linkages to low molecular weight moieties, -a⁻, which have an anionic or polyanionic character at physiological pH, and a second set of covalent linkages to peptides comprising Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinants (PNDs), or peptides immunologically equivalent therewith, is useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS), or for treating humans afflicted with HIV infection or disease.

    摘要翻译： 一种新颖的缀合物，其包含具有与低分子量部分的第一组共价键的免疫原性蛋白质或蛋白质复合物，在生理pH下具有阴离子或聚阴离子特征，以及与肽的共价键的第二组，包括 人类免疫缺陷病毒（HIV）主要中和决定簇（PND）或与其免疫学上相当的肽可用于在哺乳动物中诱导抗肽免疫应答，用于在哺乳动物中诱导HIV-中和抗体，用于配制疫苗以预防HIV感染或疾病， 包括获得性免疫缺陷综合征（AIDS），或用于治疗患有HIV感染或疾病的人。

    Assay for varicella-zoster virus (VZV) antibodies
    6.
    发明公开
    Assay for varicella-zoster virus (VZV) antibodies 失效
    测定水痘带状疱疹病毒（VZV）-Antikörper。

    公开(公告)号：EP0211756A1

    公开(公告)日：1987-02-25

    申请号：EP86401702.5

    申请日：1986-07-30

    申请人： Merck & Co., Inc.

    发明人： Ellis, Ronald W. ,  Neff, Beverly J. ,  Keller, Paul M. ,  Emini, Emilio A.

    IPC分类号： C07K15/14 ,  G01N33/569 ,  C12Q1/70 ,  C07K17/00 ,  A61K39/35

    CPC分类号： C07K14/005 ,  C07K16/088 ,  C12N2710/16722

    摘要： Antibodies in mammalian biological fluids to each of the three major VZV glycoprotein groups, gA, gB and gC, can be detected, for example, by isolating each viral glycoprotein from VZV-invected cells in vitro, adhering these to a plastic surface and contacting with a biological fluid containing the suspected antibodies. Subsequent treatment with a conjugate consisting of, for example, an antibody-enzyme complex (with specificity for either one, two or all three glycoprotein groups), followed by contact with an enzyme substrate and subsequent determination of the quantity of reacted enzyme substrate, i.e.,the ELISA assay, provides a relative measure of the antibody(ies) present directed against VZV glycoproteins.

    摘要翻译： 可以检测哺乳动物生物流体中三种主要VZV糖蛋白基团，gA，gB和gC中的每一种的抗体，例如通过在体外从VZV-插入的细胞中分离每种病毒糖蛋白，将它们粘附到塑料表面并与 含有怀疑抗体的生物液体。 随后用由例如抗体 - 酶复合物（对于一个，两个或所有三个糖蛋白基团具有特异性）组成的缀合物处理，然后与酶底物接触并随后测定反应的酶底物的量，即 ELISA测定提供了针对VZV糖蛋白存在的抗体的相对测量。

    Peptide-polysaccharide-protein conjugate vaccines
    8.
    发明公开
    Peptide-polysaccharide-protein conjugate vaccines 失效
    肽多糖 - 蛋白质结合疫苗

    公开(公告)号：EP0468714A3

    公开(公告)日：1993-03-10

    申请号：EP91306620.5

    申请日：1991-07-19

    申请人： MERCK & CO. INC.

    发明人： Marburg, Stephen ,  Tolman, Richard L. ,  Emini, Emilio A.

    IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K7/10 ,  C07K7/52 ,  C07K7/54 ,  C07K17/10 ,  C07K15/04 ,  A61K47/48 ,  A61K39/21 ,  A61K37/02

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2740/16122

    摘要： Covalent conjugate immunogens, having Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides covalently bound to the Outer Membrane Protein Complex (OMPC) of Neisseria through a linker which is an anionic polysaccharide (PSA), are useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS) or for treating humans afflicted with HIV infection or HIV disease, including AIDS.

    摘要翻译： 通过作为阴离子多糖（PSA）的接头共价结合奈瑟氏球菌的外膜蛋白复合物（OMPC）的人免疫缺陷病毒（HIV）的主要中和决定簇（PND）肽的共价结合免疫原可用于诱导抗肽 哺乳动物中的免疫反应，用于在哺乳动物中诱导HIV-中和抗体，用于配制预防HIV感染或疾病的疫苗，包括获得性免疫缺陷综合征（AIDS）或用于治疗患有HIV感染或HIV疾病（包括AIDS）的人。