-
公开(公告)号：EP1924593B1
公开(公告)日：2009-09-16
申请号：EP06787475.0
申请日：2006-07-14
申请人： Merck & Co., Inc.
发明人： HOLLOWAY, M. Katharine , LIVERTON, Nigel, J. , LUDMERER, Steven, W. , MCCAULEY, John, A. , OLSEN, David, B. , RUDD, Michael, T. , VACCA, Joseph, P. , MCINTYRE, Charles, J.
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0812 , C07K5/0827
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
-
公开(公告)号：EP1924593A1
公开(公告)日：2008-05-28
申请号：EP06787475.0
申请日：2006-07-14
申请人： Merck & Co., Inc.
发明人： HOLLOWAY, M. Katharine , LIVERTON, Nigel, J. , LUDMERER, Steven, W. , MCCAULEY, John, A. , OLSEN, David, B. , RUDD, Michael, T. , VACCA, Joseph, P. , MCINTYRE, Charles, J.
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0812 , C07K5/0827
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
-
3.发明公开MACROCYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权万家乐CYCLICAL螺哌啶β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP2073635A1
公开(公告)日：2009-07-01
申请号：EP07839182.8
申请日：2007-10-02
申请人： Merck & Co., Inc.
IPC分类号： A01N43/40 , A61K31/415
CPC分类号： C07D471/10 , C07D471/20
摘要： The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
-
公开(公告)号：EP1924593B8
公开(公告)日：2009-11-18
申请号：EP06787475.0
申请日：2006-07-14
申请人： Merck & Co., Inc.
发明人： HOLLOWAY, M. Katharine , LIVERTON, Nigel, J. , LUDMERER, Steven, W. , MCCAULEY, John, A. , OLSEN, David, B. , RUDD, Michael, T. , VACCA, Joseph, P. , MCINTYRE, Charles, J.
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0812 , C07K5/0827
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
-
公开(公告)号：EP1879607A2
公开(公告)日：2008-01-23
申请号：EP06751833.2
申请日：2006-04-28
申请人： Merck & Co., Inc.
发明人： HOLLOWAY, M. Katharine , LIVERTON, Nigel, J. , LUDMERER, Steven, W. , MCCAULEY, John, A. , OLSEN, David, B. , RUDD, Michael, T. , VACCA, Joseph, P.
IPC分类号： A61K38/12
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0821
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. I
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂的有用的式（I）的大环化合物，它们的合成及其用于治疗或预防HCV感染的用途。 一世
-
6.发明公开2-AMINOPYRIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权2- AMINOPYRIDINZUSAMMENSETZUNGEN ALSβ-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1807396A1
公开(公告)日：2007-07-18
申请号：EP05851361.5
申请日：2005-10-25
申请人： Merck & Co., Inc.
IPC分类号： C07D211/72 , A61K31/44
CPC分类号： C07D213/73
摘要： The present invention is directed to 2-aminopyridine compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
-
7.发明公开
公开(公告)号：EP1732906A1
公开(公告)日：2006-12-20
申请号：EP05733551.5
申请日：2005-03-25
申请人： Merck & Co., Inc.
发明人： COBURN, Craig, A. , ESPESETH, Amy, S. , STACHEL, Shawn, J. , OLSEN, David, B. , HAZUDA, Daria, J. , HOLLOWAY, M. Katharine
IPC分类号： C07D277/60
CPC分类号： C07D417/14 , C07D277/40 , C07D277/60 , C07D277/82 , C07D277/84 , C07D417/04 , C07D417/06 , C07D417/08
摘要： The present invention is directed to 2-aminothiazole compounds which are aspartyl protease inhibitors, and are inhibitors of both the beta-secretase enzyme and HIV protease, and that are useful in the treatment of diseases in which the beta-secretase enzyme and HIV are involved, such as Alzheimer's disease, HIV Infection and AIDS. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme and HIV protease are involved.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.012 秒)
