专利检索 ap:("Merck & Co., Inc.") AND inv:"WANG, Liping" 第 1 页

1.

发明公开
3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 审中-公开
标题翻译： 3-氨基-4-苯基丁酸衍生物作为二肽基肽酶抑制剂对于糖尿病的治疗或预防

公开(公告)号：EP1583534A1

公开(公告)日：2005-10-12

申请号：EP03814066.1

申请日：2003-12-16

申请人： Merck & Co., Inc.

发明人： DUFFY, Joseph, L. , EDMONDSON, Scott, D. , KIM, Dooseop , KIRK, Brian, A. , WANG, Liping , WEBER, Ann, E.

IPC分类号： A61K31/497 , C07D403/00

CPC分类号： C07D487/04

摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

2.

发明公开
CYCLIC AMINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开
标题翻译：趋化因子受体的环胺调节剂

公开(公告)号：EP1052992A1

公开(公告)日：2000-11-22

申请号：EP99906697.0

申请日：1999-02-01

申请人： MERCK & CO., INC.

发明人： CALDWELL, Charles, G. , FINKE, Paul, E. , MACCOSS, Malcolm , MILLS, Sander, G. , OATES, Bryan , KIM, Dooseop , KOTHANDARAMAN, Shankaran , WANG, Liping

IPC分类号： A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , C07D211/18 , C07D211/32 , C07D211/36 , C07D211/96 , C07D401/06 , C07D401/14 , C07D407/14 , C07D409/10 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/107

CPC分类号： C07D231/12 , C07D211/56 , C07D233/56 , C07D249/08 , C07D401/06 , C07D405/06 , C07D409/06

摘要： The present invention is directed to cyclic amines of formula I (wherein R?1, R2, R3¿, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

3.

发明公开
3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 审中-公开
标题翻译： 3-氨基-4-PHENYLBUTANSÄUREDERIVATEALS抑制剂的二肽为糖尿病治疗或预防

公开(公告)号：EP1592689A2

公开(公告)日：2005-11-09

申请号：EP04705717.9

申请日：2004-01-27

申请人： Merck & Co., Inc.

发明人： ASHTON, Wallace, T. , CALDWELL, Charles, G. , DUFFY, Joseph, L. , MATHVINK, Robert, J. , WANG, Liping , WEBER, Ann, E.

IPC分类号： C07D471/04 , C07D487/04 , A61K31/4375 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P3/10

CPC分类号： C07D471/04 , C07D217/06 , C07D217/26

摘要： The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.