公开(公告)号：EP1180100A2

公开(公告)日：2002-02-20

申请号：EP00918641.2

申请日：2000-04-19

申请人： Merck Frosst Canada & Co.

发明人： FRENETTE, Richard ,  FRIESEN, Richard ,  GIRARD, Mario ,  GIRARD, Yves ,  GODBOUT, Cedrickx ,  GUAY, Daniel ,  HAMEL, Pierre ,  PERRIER, Helene

IPC分类号： C07D213/89 ,  C07D213/64 ,  C07D409/14 ,  C07D417/14 ,  C07D213/79 ,  C07D213/76 ,  C07D405/14 ,  A61K31/4427 ,  A61P11/00

CPC分类号： C07D213/64 ,  C07D213/76 ,  C07D213/79 ,  C07D213/89 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). The invention also encompasses pharmaceutical compositions and methods for treatment.