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1.发明公开
公开(公告)号：EP1397359A1
公开(公告)日：2004-03-17
申请号：EP02727127.9
申请日：2002-05-22
发明人： GUAY, Daniel , GIRARD, Mario , HAMEL, Pierre , LALIBERTE, Sebastien , FRIESEN, Richard , GIRARD, Yves , LI, Chun
IPC分类号： C07D471/04 , A61K31/435 , A61K31/495 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are phosphodiesterase-4 inhibitors useful in the treatment of asthma and inflammation.
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2.发明公开ALKYNE-ARYL-NAPHTHYRIDIN-4(1H)-0NE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITOR 有权炔芳基萘啶-4（1H）-0NE衍生物作为IV型磷酸的抑制剂
公开(公告)号：EP1436290A1
公开(公告)日：2004-07-14
申请号：EP02754079.8
申请日：2002-08-27
IPC分类号： C07D471/04 , C07D519/00 , A61K31/435
CPC分类号： A61K45/06 , A61K31/435 , A61K31/4375 , C07D471/04 , A61K2300/00
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are phosphodiesterase 4 inhibitors useful in the treatment of asthma and inflammation.
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公开(公告)号：EP1272488B1
公开(公告)日：2006-03-22
申请号：EP01914905.3
申请日：2001-03-19
发明人： FRIESEN, Richard , DUCHARME, Yves , COTE, Bernard , BLOUIN, Marc , MARTINS, Evelyn , GUAY, Daniel , HAMEL, Pierre , GIRARD, Mario , FRENETTE, Richard , LALIBERTE, Sebastien
IPC分类号： C07D417/08 , A61P37/00 , C07D417/06 , C07D417/14 , A61K31/427
CPC分类号： C07D417/06
摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.
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4.发明授权3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS 失效3,4-二芳基-2-羟基-2,5-二氢呋喃作为COX-2抑制剂的活性成分的前体
公开(公告)号：EP0904269B1
公开(公告)日：2002-01-23
申请号：EP96934267.4
申请日：1996-10-29
发明人： BLACK, Cameron , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin , HAMEL, Pierre , HAN, Yongxin , HUGHES, Gregory
IPC分类号： C07D307/32 , A61K31/34 , A61K31/44 , A61K31/18 , C07D307/30 , C07C317/22 , C07D213/30 , C07F9/117 , C07D307/94 , C07D405/12 , C07D417/12
CPC分类号： C07D307/32 , C07C317/22 , C07C323/64 , C07D213/34 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/94 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07F9/117
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公开(公告)号：EP1592419A1
公开(公告)日：2005-11-09
申请号：EP03776698.7
申请日：2003-11-19
发明人： DUBE, Daniel , GALLANT, Michel , LACOMBE, Patrick , GIRARD, Yves , MACDONALD, Dwight , FRIESEN, Richard , DUCHARME, Yves , COTE, Bernard , BLOUIN, Marc , MARTINS, Evelyn , GUAY, Daniel , GIRARD, Mario , FRENETTE, Richard , LALIBERTE, Sebastien , ROBICHAUD, Annette , MASTRACCHIO, Anthony , PERRIER, Helene , HAMEL, Pierre
IPC分类号： A61K31/277 , A61K31/44 , A61K31/4375 , A61K31/47 , A61P25/00 , A61P25/28
CPC分类号： A61K31/4709 , A61K31/277 , A61K31/4375 , A61K31/44 , A61K31/47
摘要： The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.
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6.发明授权
公开(公告)号：EP1397359B1
公开(公告)日：2005-08-31
申请号：EP02727127.9
申请日：2002-05-22
发明人： GUAY, Daniel , GIRARD, Mario , HAMEL, Pierre , LALIBERTE, Sebastien , FRIESEN, Richard , GIRARD, Yves , LI, Chun
IPC分类号： C07D471/04 , A61K31/435 , A61K31/495 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are phosphodiesterase-4 inhibitors useful in the treatment of asthma and inflammation.
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公开(公告)号：EP1180100A2
公开(公告)日：2002-02-20
申请号：EP00918641.2
申请日：2000-04-19
发明人： FRENETTE, Richard , FRIESEN, Richard , GIRARD, Mario , GIRARD, Yves , GODBOUT, Cedrickx , GUAY, Daniel , HAMEL, Pierre , PERRIER, Helene
IPC分类号： C07D213/89 , C07D213/64 , C07D409/14 , C07D417/14 , C07D213/79 , C07D213/76 , C07D405/14 , A61K31/4427 , A61P11/00
CPC分类号： C07D213/64 , C07D213/76 , C07D213/79 , C07D213/89 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). The invention also encompasses pharmaceutical compositions and methods for treatment.
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