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公开(公告)号：EP1019399A1
公开(公告)日：2000-07-19
申请号：EP98946190.0
申请日：1998-10-01
发明人： HAN, Yongxin , MacDONALD, Dwight , GIROUX, Andre , YOUNG, Robert, N. , PERRIER, Helene , LEPINE, Carole
IPC分类号： C07D409/12 , C07D409/14 , C07D417/14 , C07D333/24 , C07D409/04 , C07D333/16 , A61K31/38
CPC分类号： C07D409/14 , C07D333/24 , C07D409/04 , C07D409/12 , C07D417/14
摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).
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2.发明授权
公开(公告)号：EP1363635B1
公开(公告)日：2009-04-15
申请号：EP01273908.2
申请日：2001-12-14
发明人： VAILAYA, Anant , CONLON, David, A. , HO, Guo-Jie , MACDONALD, Dwight , PERRIER, Helene , THIBERT, Roch , KWONG, Elizabeth , CLAS, Sophie-Dorothee
IPC分类号： A61K31/47 , C07D215/12 , C07D215/14 , C07D401/10 , C07D413/10 , C07D417/10 , A61P11/00
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D413/10 , C07D417/10
摘要： Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
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公开(公告)号：EP1592419A1
公开(公告)日：2005-11-09
申请号：EP03776698.7
申请日：2003-11-19
发明人： DUBE, Daniel , GALLANT, Michel , LACOMBE, Patrick , GIRARD, Yves , MACDONALD, Dwight , FRIESEN, Richard , DUCHARME, Yves , COTE, Bernard , BLOUIN, Marc , MARTINS, Evelyn , GUAY, Daniel , GIRARD, Mario , FRENETTE, Richard , LALIBERTE, Sebastien , ROBICHAUD, Annette , MASTRACCHIO, Anthony , PERRIER, Helene , HAMEL, Pierre
IPC分类号： A61K31/277 , A61K31/44 , A61K31/4375 , A61K31/47 , A61P25/00 , A61P25/28
CPC分类号： A61K31/4709 , A61K31/277 , A61K31/4375 , A61K31/44 , A61K31/47
摘要： The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.
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4.发明公开
公开(公告)号：EP1363635A1
公开(公告)日：2003-11-26
申请号：EP01273908.2
申请日：2001-12-14
发明人： VAILAYA, Anant , CONLON, David, A. , HO, Guo-Jie , MACDONALD, Dwight , PERRIER, Helene , THIBERT, Roch , KWONG, Elizabeth , CLAS, Sophie-Dorothee
IPC分类号： A61K31/47 , C07D215/12 , C07D215/14 , C07D401/10 , C07D413/10 , C07D417/10 , A61P11/00
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D413/10 , C07D417/10
摘要： Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
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公开(公告)号：EP1180100A2
公开(公告)日：2002-02-20
申请号：EP00918641.2
申请日：2000-04-19
发明人： FRENETTE, Richard , FRIESEN, Richard , GIRARD, Mario , GIRARD, Yves , GODBOUT, Cedrickx , GUAY, Daniel , HAMEL, Pierre , PERRIER, Helene
IPC分类号： C07D213/89 , C07D213/64 , C07D409/14 , C07D417/14 , C07D213/79 , C07D213/76 , C07D405/14 , A61K31/4427 , A61P11/00
CPC分类号： C07D213/64 , C07D213/76 , C07D213/79 , C07D213/89 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). The invention also encompasses pharmaceutical compositions and methods for treatment.
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