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公开(公告)号：EP3784666A1
公开(公告)日：2021-03-03
申请号：EP19726792.5
申请日：2019-04-23
发明人： YU, Henry , CLARK, Michael , BEMIS, Guy , BOYD, Michael , CHANDUPATLA, Kishan , COLLIER, Philip , DENG, Hongbo , DONG, Huijun , DORSCH, Warren , HOOVER, Russell, R. , JOHNSON, Mac, Arthur, JR. , KUKAMI, Shashank , PENNEY, Marina , RONKIN, Steven , TAKEMOTO, Darin , TANG, Qing , WAAL, Nathan, D. , WANG, Tiansheng , LAUFFER, David J. , LI, Pan
IPC分类号： C07D413/14 , C07D403/04 , C07D409/14 , C07D413/04 , A61K31/553 , A61P35/00
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公开(公告)号：EP4043460A1
公开(公告)日：2022-08-17
申请号：EP22161962.0
申请日：2019-04-23
发明人： KULKARNI, Shashank , YU, Henry , CLARK, Michael , BEMIS, Guy , BOYD, Michael , CHANDUPATLA, Kishan , COLLIER, Philip , DENG, Hongbo , DONG, Huijun , DORSCH, Warren , HOOVER, Russell, R. , JOHNSON, Mac, Arthur, JR. , PENNEY, Marina , RONKIN, Steven , TAKEMOTO, Darin , TANG, Qing , WAAL, Nathan, D. , WANG, Tiansheng , LAUFFER, David J. , LI, Pan
IPC分类号： C07D413/14 , C07D403/04 , C07D409/14 , C07D413/04 , A61K31/553 , A61P35/00
摘要： The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).
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公开(公告)号：EP3527563A1
公开(公告)日：2019-08-21
申请号：EP18207382.5
申请日：2014-03-12
发明人： MAXWELL, John, Patrick , CHARIFSON, Paul, S. , TANG, Qing , RONKIN, Steven, M. , JACKSON, Katrina, Lee , PIERCE, Albert, Charles , LAUFFER, David, J. , LI, Pan , GIROUX, Simon , XU, Jinwang , MORRIS, Mark, A. , COURT, John, J. , COTTRELL, Kevin, M. , DENG, Hongbo , WAAL, Nathan, D. , GU, Wenxin
IPC分类号： C07D403/12 , C07D405/12 , C07D413/04 , C07D241/44 , C07D417/12 , C07D491/052 , A61K31/517 , A61P35/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP2970218B8
公开(公告)日：2019-04-10
申请号：EP14719434.4
申请日：2014-03-12
发明人： MAXWELL, John, Patrick , CHARIFSON, Paul, S. , TANG, Qing , RONKIN, Steven, M. , JACKSON, Katrina, Lee , PIERCE, Albert, Charles , LAUFFER, David, J. , LI, Pan , GIROUX, Simon , XU, Jinwang , MORRIS, Mark, A. , COURT, John, J. , COTTRELL, Kevin, M. , DENG, Hongbo , WAAL, Nathan, D. , GU, Wenxin
IPC分类号： C07D403/12 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052 , A61K31/517 , A61P35/00
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公开(公告)号：EP2841428A1
公开(公告)日：2015-03-04
申请号：EP13719359.5
申请日：2013-04-23
发明人： GAO, Huai , CHARIFSON, Paul, S. , COTTRELL, Kevin,Michael , DENG, Hongbo , DUFFY, John, P. , GIROUX, Simon , GREEN, Jeremy , JACKSON, Katrina, Lee , MAXWELL, John, Patrick , MORRIS, Mark, A. , PIERCE, Albert, Charles , WAAL, Nathan, D. , LAUFFER, David, J. , KENNEDY, Joseph, M. , LEDEBOER, Mark, Willem , LI, Pan , XU, Jinwang
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP3784669A1
公开(公告)日：2021-03-03
申请号：EP19726791.7
申请日：2019-04-23
发明人： LAUFFER, David, J. , BEMIS, Guy , BOYD, Michael , DEININGER, David , DENG, Hongbo , DORSCH, Warren , GU, Wenxin , HOOVER, Russell, R. , JOHNSON, Mac, Arthur, Jr. , LEDEBOER, Mark, Willem , LEDFORD, Brian , MALTAIS, Francois , PENNEY, Marina , TAKEMOTO, Darin , WAAL, Nathan, D. , WENG, Tiansheng , LI, Pan
IPC分类号： C07D471/04 , C07D475/04 , A61P35/00 , A61K31/505
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公开(公告)号：EP3057959B1
公开(公告)日：2018-02-28
申请号：EP14800181.1
申请日：2014-10-17
发明人： CHARIFSON, Paul, S. , COTTRELL, Kevin, Michael , DENG, Hongbo , DUFFY, John, P. , GAO, Huai , GIROUX, Simon , GREEN, Jeremy , JACKSON, Katrina, Lee , KENNEDY, Joseph, M. , LAUFFER, David, J. , LEDEBOER, Mark, Willem , LI, Pan , MAXWELL, John, Patrick , MORRIS, Mark, A. , PIERCE, Albert, Charles , WAAL, Nathan, D. , XU, Jinwang
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D403/14 , C07D471/04 , C07D493/04 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：EP3057959A1
公开(公告)日：2016-08-24
申请号：EP14800181.1
申请日：2014-10-17
发明人： CHARIFSON, Paul, S. , COTTRELL, Kevin, Michael , DENG, Hongbo , DUFFY, John, P. , GAO, Huai , GIROUX, Simon , GREEN, Jeremy , JACKSON, Katrina, Lee , KENNEDY, Joseph, M. , LAUFFER, David, J. , LEDEBOER, Mark, Willem , LI, Pan , MAXWELL, John, Patrick , MORRIS, Mark, A. , PIERCE, Albert, Charles , WAAL, Nathan, D. , XU, Jinwang
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D403/14 , C07D471/04 , C07D493/04 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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